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  • Oncogenomics
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Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis

Oncogene volume 23, pages 3495–3500 (2004)Cite this article

Abstract

Functional inactivation of tuberous sclerosis 2 gene (Tsc2) leads to renal carcinogenesis in the hereditary renal carcinoma Eker rat models. Recent studies revealed a role of tuberin, a TSC2 product, in suppressing the p70 S6 kinase (p70S6K) activity via inhibition of mammalian target of rapamycin (mTOR). Phosphorylated S6 protein, a substrate of p70S6K, was expressed in the early lesions in Eker rats, and this expression was suppressed by the treatment of rapamycin, an inhibitor of mTOR. We previously isolated the novel gene Niban expressed in renal carcinogenesis of Eker rats. In this study, we demonstrated that the expression of Niban was detected from early preneoplastic lesions in Eker rats. Interestingly, in contrast to the phosphorylated S6 protein, the expression of Niban was unchanged and early lesions still remained even after treatment with rapamycin. These results might suggest the existence of another pathway independent of mTOR-S6K pathway in Tsc2 mutant renal carcinogenesis. In addition, Niban was also expressed in other renal carcinoma models, including Tsc1 and Tsc2 knockout mice, and various types of human renal cell carcinomas. Thus, Niban was commonly expressed in renal carcinomas and might be a new marker for renal carcinogenesis.

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Acknowledgements

We thank Drs K Okimoto (Nihon rats) and R Takahashi (SV40 large T antigen transgenic rats) for making available unpublished data. We also thank Dr I Fukui for supplying human samples. This work is supported in part by Grants-in-Aid for Cancer Research from the Ministry of Education, Culture, Sports and Science Technology of Japan and the Ministry of Health, Labour and Welfare of Japan.

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Authors and Affiliations

  1. Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo, 170-8455, Japan

    Hiroyuki Adachi, Shuichi Majima, Shigeyuki Kon, Toshiyuki Kobayashi, Kazunori Kajino, Hiroaki Mitani, Youko Hirayama & Okio Hino

  2. Department of Urology, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan

    Hiroyuki Adachi, Hiroaki Shiina & Mikio Igawa

  3. Immuno-Biological Laboratories Co., Ltd., 1091-1 Naka, Fujioka-shi, Gunma, 375-0005, Japan

    Shigeyuki Kon

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  1. Hiroyuki Adachi
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  2. Shuichi Majima
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  3. Shigeyuki Kon
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Correspondence to Okio Hino.

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Adachi, H., Majima, S., Kon, S. et al. Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis. Oncogene 23, 3495–3500 (2004). https://doi.org/10.1038/sj.onc.1207468

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