Abstract
A role for the p52 NF-κB subunit in tumorigenesis has been steadily emerging since its discovery as a gene associated with chromosomal translocations in B- and T-cell lymphomas. Now Eliopoulos and co-workers have extended these studies to examine the effect of the Epstein–Barr virus (EBV)-encoded latent infection membrane protein 1 (LMP1) on p52. They find that LMP1 stimulates the processing of p100 to p52 NF-κB. Moreover, nuclear p52 is also associated with LMP1 expression in tumor tissue biopsies. They also demonstrate that the pathway leading to p100/p52 processing is distinct from that engaged by LMP1 to activate other NF-κB subunits through IκBα degradation. A clearer picture is now developing of the important role that p52 NF-κB plays during normal cell growth and how subverting its function can contribute to oncogenesis.
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References
Baldwin AS . (2001). J. Clin. Invest., 107, 241–246.
Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck R, Bravo R, Kelly K and Siebenlist U . (1992). Mol. Cell. Biol., 12, 685–695.
Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K and Siebenlist U . (1993). Cell, 72, 729–739.
Budunova IV, Perez P, Vaden VR, Spiegelman VS, Slaga TJ and Jorcano JL . (1999). Oncogene, 18, 7423–7431.
Cahir-McFarland ED, Izumi KM and Mosialos G . (1999). Oncogene, 18, 6959–6964.
Cao YX, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV and Karin M . (2001). Cell, 107, 763–775.
Chang CC, Zhang JD, Lombardi L, Neri A and Dallafavera R . (1995). Mol. Cell. Biol., 15, 5180–5187.
Ciana P, Neri A, Cappellini C, Cavallo F, Pomati M, Chang CC, Maiolo AT and Lombardi L . (1997). Oncogene, 14, 1805–1810.
Cogswell PC, Guttridge DC, Funkhouser WK and Baldwin AS . (2000). Oncogene, 19, 1123–1131.
Coope HJ, Atkinson PGP, Huhse B, Belich M, Janzen J, Holman MJ, Klaus GGB, Johnston LH and Ley SC . (2002). EMBO J., 21, 5375–5385.
Dejardin E, Droin NM, Delhase M, Haas E, Cao YX, Makris C, Li ZW, Karin M, Ware CF and Green DR . (2002). Immunity, 17, 525–535.
Duckett CS, Perkins ND, Kowalik TF, Schmid RM, Huang ES, Baldwin Jr AS and Nabel GJ . (1993). Mol. Cell. Biol., 13, 1315–1322.
Fracchiolla NS, Lombardi L, Salina M, Migliazza A, Baldini L, Berti E, Cro L, Polli E, Maiolo AT and Neri A . (1993). Oncogene, 8, 2839–2845.
Fujita T, Nolan GP, Ghosh S and Baltimore D . (1992). Genes Dev., 6, 775–787.
Garg A and Aggarwal BB . (2002). Leukemia, 16, 1053–1068.
Heusch M, Lin L, Geleziunas R and Greene WC . (1999). Oncogene, 18, 6201–6208.
Ishikawa H, Carrasco D, Claudio E, Ryseck RP and Bravo R . (1997). J. Exp. Med., 186, 999–1014.
Jo H, Zhang R, Zhang H, McKinsey TA, Shao J, Beauchamp RD, Ballard DW and Liang P . (2000). Oncogene, 19, 841–849.
Kayagaki N, Yan MH, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin JP, Starovasnik MA and Dixit VM . (2002). Immunity, 17, 515–524.
Laherty CD, Hu HM, Opipari AW, Wang F and Dixit VM . (1992). J. Biol. Chem., 267, 24157–24160.
Liptay S, Schmid RM, Nabel EG and Nabel GJ . (1994). Mol. Cell. Biol., 14, 7695–7703.
Mayo MW, Wang CY, Cogswell PC, RogersGraham KS, Lowe SW, Der CJ and Baldwin AS . (1997). Science, 278, 1812–1815.
McKeithan TW, Takimoto GS, Ohno H, Bjorling VS, Morgan R, Hecht BK, Dube I, Sandberg AA and Rowley JD . (1997). Genes Chromosomes Cancer, 20, 64–72.
Michaux L, Mecucci C, Stul M, Wlodarska I, Hernandez JM, Meeus P, Michaux JL, Scheiff JM, Noel H, Louwagie A, Criel A, Boogaerts M, VanOrshoven A, Cassiman JJ and VandenBerghe H . (1996). Genes Chromosomes Cancer, 15, 38–47.
Mordmuller B, Krappmann D, Esen M, Wegener E and Scheidereit C . (2003). EMBO Rep., 4, 82–87.
Mosialos G . (1997). Semin. Cancer Biol., 8, 121–129.
Muller JR and Siebenlist U . (2003). J. Biol. Chem., 278, 12006–12012.
Nabel G and Baltimore D . (1987). Nature, 326, 711–713.
Neri A, Chang CC, Lombardi L, Salina M, Corradini P, Maiolo AT, Chaganti RSK and Dalla-Favera R . (1991). Cell, 67, 1075–1087.
Nolan GP, Fujita T, Bhatia K, Huppi C, Liou HC, Scott ML and Baltimore D . (1993). Mol. Cell. Biol., 13, 3557–3566.
Perkins ND . (2000). Trends Biochem. Sci., 25, 434–440.
Perkins ND, Agranoff AB, Pascal E and Nabel GJ . (1994). Mol. Cell. Biol., 14, 6570–6583.
Reuther JY, Reuther GW, Cortez D, Pendergast AM and Baldwin AS . (1998). Genes Dev., 12, 968–981.
Rocha S, Martin AM, Meek DW and Perkins ND . (2003). Mol. Cell. Biol., 23, 4713–4727.
Saccani S, Pantano S and Natoli G . (2003). Mol. Cell, 11, 1563–1574.
Schmid RM, Perkins ND, Duckett CS, Andrews PC and Nabel GJ . (1991). Nature, 352, 733–736.
Senftleben U, Cao YX, Xiao GT, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu YL, Fong A, Sun SC and Karin M . (2001). Science, 293, 1495–1499.
Thakur S, Lin H, Tseng W, Kumar S, Bravo R, Foss F, Gelinas C and Rabson AB . (1994). Oncogene, 9, 2335–2344.
Viatour P, Bentires-Alj M, Chariot A, Deregowski V, de Leval L, Merville MP and Bours V . (2003). Leukemia, 17, 1349–1356.
Wang YQ, Cui HJ, Schroering A, Ding JL, Lane WS, McGill G, Fisher DE and Ding HF . (2002). Nat. Cell Biol., 4, 888–893.
Weinstatsaslow D, Merino MJ, Manrow RE, Lawrence JA, Bluth RF, Wittenbel KD, Simpson JF, Page DL and Steeg PS . (1995). Nat. Med., 1, 1257–1260.
Westerheide SD, Mayo MW, Anest V, Hanson JL and Baldwin AS . (2001). Mol. Cell. Biol., 21, 8428–8436.
Xiao GT, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M and Sun SC . (2001). EMBO J., 20, 6805–6815.
Acknowledgements
NDP is the recipient of a Royal Society University Research Fellowship.
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Commentary article on Eliopoulos et al. ‘Epstein–Barr virus-encoded latent infection membrane protein 1 (LMP1) regulates the processing of p100 NF-κB to p52 via an IKKγ/NEMO-independent signaling pathway’
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