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Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer

Oncogene volume 20, pages 3929–3936 (2001)Cite this article

Abstract

Although apoptosis plays an essential role in the embryogenesis and homeostasis of multicellular organisms, this mechanism has not yet been fully clarified. We isolated a novel human apoptosis-inducing gene, ASY, which encodes an endoplasmic reticulum-targeting protein without any known apoptosis-related motifs. This gene is identical to the Nogo-B, a splice variant of the Nogo-A which has recently been shown to be an inhibitor of neuronal regeneration in the central nervous system. Ectopic expression of the ASY gene led to extensive apoptosis, particularly in cancer cells. Furthermore, transcription of the ASY gene was suppressed in small cell lung cancer. These results suggest that a new type of apoptosis-inducing gene, namely, ASY, may be involved in the development of certain types of cancer.

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References

  • Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J . 1996 Cell 87: 171

  • Ashkenazi A, Dixit VM . 1998 Science 281: 1305–1308

  • Banerjee A, Xu H-J, Hu S-X, Araujo D, Takahashi R, Stanbridge EJ, Benedict WF . 1992 Cancer Res. 52: 6297–6304

  • Bellacosa A, Testa JR, Staal SP, Tsichlis PN . 1991 Science 254: 274–277

  • Chen MS, Huber AB, van der Haar ME, Frank M, Schnell AA, Spillmann AA, Christ F, Schwab ME . 2000 Nature 403: 434–439

  • Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S . 1998 Nature 391: 43–50

  • GrandPre T, Nakamura F, Vartanian T, Strittmatter SM . 2000 Nature 403: 439–444

  • Green DR, Reed JC . 1998 Science 281: 1309–1312

  • Hollstein M, Sidransky D, Vogelstein B, Harris C . 1991 Science 253: 49–53

  • Jackson MR, Nilsson T, Peterson PA . 1990 EMBO J. 9: 3153–3162

  • Johnson P, Gray D, Mowat M, Benchimol S . 1991 Mol. Cell. Biol. 11: 1–11

  • Kelakar A, Thompson CB . 1998 Trends Cell Biol. 8: 324–330

  • Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT . 1997 Science 287: 294–298

  • Kroemer G . 1997 Nature Med. 3: 614–620

  • Margolskee RF, Kavathas P, Berg P . 1988 Mol. Cell. Biol. 8: 2837–2847

  • Martin SJ, Reutelingsperqer CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, Green DR . 1995 J. Exp. Med. 182: 1545–1557

  • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner B, Yuan J . 2000 Nature 403: 98–103

  • Oka K, Tomonaga Y, Nakazawa T, Ge H-Y, Bengtsson U, Stanbridge EJ, Yoshioka N, Li Q, Hakura A, Yutsudo M . 1999 Genes, Chromosomes Cancer 26: 47–53

  • Prinjha R, Moore SE, Vinson M, Blake S, Morrow G, Christie G, Michalovich D, Simmons DL, Walsh FS . 2000 Nature 403: 383–384

  • Roebroek AJM, Martens GJ, Duits AJ, Schalken JA, van Bokhoven A, Wagenaar SS, van de Ven WJ . 1989 Cancer Res. 49: 4154–4158

  • Roebroek AJM, van de Velde HJ, van Bokhoven A, Broera JL, Ramaekers FC, van de Ven WJ . 1993 J. Biol. Chem. 268: 13439–13447

  • Shimakage M, Nakamine H, Tamura S, Takenaka T, Yutsudo M, Hakura A . 1997 Human Pathol. 28: 1415–1419

  • Stanbridge EJ, Der CJ, Doersen CJ, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE . 1982 Science 215: 252–259

  • Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM . 1984 Science 226: 1097–1099

  • Urano F, Wang XZ, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D . 2000 Science 287: 664–666

  • Wang H-G, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, Makeon T, Bobo T, Franke TF, Reed JC . 1999 Science 284: 339–343

  • White E . 1996 Genes Dev. 10: 1–15

  • Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM . 1997 J. Biol. Chem. 272: 7797–7800

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Acknowledgements

The authors are grateful to RF Margolskee for providing EBO-pSV2neo, Y Tsujimoto for pCAGGS-hBcl-2, H Okayama and H Nojima for pcD-based human cDNA libraries and the Japanese Cancer Research Resources Bank for HT1080 and MeWo cell lines. We also thank K Tomiyama for excellent technical assistance.

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Author notes

  1. Qin Li and Bing Qi: Q Li and B Qi contributed equally to this work

Authors and Affiliations

  1. Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, 565-0871, Suita, Japan

    Qin Li, Bing Qi, Kiyomasa Oka, Naohisa Yoshioka, Hirokazu Inoue, Akira Hakura & Masuo Yutsudo

  2. Virus Institute, School of Life Science, Wuhan University, Wuhan, 430072, Hubei, China

    Bing Qi

  3. Clinical Research Institute, Osaka National Hospital, Osaka, 540-0006, Japan

    Misuzu Shimakage

  4. Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, 537-8511, Japan

    Ken Kodama

  5. Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, 92697-4025, California, CA, USA

    Eric J Stanbridge

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  1. Qin Li
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  2. Bing Qi
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  3. Kiyomasa Oka
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Correspondence to Masuo Yutsudo.

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Li, Q., Qi, B., Oka, K. et al. Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. Oncogene 20, 3929–3936 (2001). https://doi.org/10.1038/sj.onc.1204536

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