Oncogene
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9 December 2000, Volume 19, Number 53, Pages 6122-6129
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Original Paper
Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis
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Anne Saaristo, Terhi Karpanen and Kari Alitalo
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Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, University of Helsinki, Helsinki, Finland

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Correspondence to: K Alitalo, Molecular/Cancer Biology Laboratory, Haartman Institute, P.O.B. 21 (Haartmaninkatu 3), University of Helsinki, FIN-00014 Helsinki, Finland

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Abstract
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There is a constant requirement for vascular supply in solid tumors. Tumor-associated neovascularization allows the tumor cells to express their critical growth advantage. Axillary lymph node status is the most important prognostic factor in operable breast cancer, and experimental and clinical evidence suggests that the process of metastasis is also angiogenesis-dependent. Various angiogenic growth factors and cytokines induce neovascularization in tumors, namely members of the vascular endothelial growth factor (VEGF) and angiopoietin (Ang) gene families. A strong correlation has been found between VEGF expression and increased tumor microvasculature, malignancy, and metastasis in breast cancer. Anti-angiogenic therapy approaches offer a new promising anti-cancer strategy and a remarkably diverse group of over 20 such drugs is currently undergoing evaluation in clinical trials. Oncogene (2000) 19, 6122-6129.

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Keywords
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breast cancer; metastasis; lymphatic vessels; VEGF; VEGF-C

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9 December 2000, Volume 19, Number 53, Pages 6122-6129
Table of contents    Previous  Abstract  Next   Full text  PDF