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| 24 December 1998, Volume 17, Number 25, Pages 3365-3383 |
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| Review article |
| Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth |
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| Xavier Graña1,a, Judit Garriga1 and Xavier Mayol2 |
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1Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 North Broad St., Philadelphia, PA19140, USA
2Unitat de Biologia Cel.lular i Molecular, Institut Municipal d' Investigació Medica (IMIM), Dr. Aiguader 80, 08003 Barcelona, Spain
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aAuthor for correspondence: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, AHP bldg., room 553, 3307 North Broad St., Philadelphia, PA19140, USA |
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| Abstract |
| The retinoblastoma family of proteins, also known as pocket proteins, includes the product of the retinoblastoma susceptibility gene and the functionally and structurally related proteins p107 and p130. Pocket proteins control growth processes in many cell types, and this has been linked to the ability of pocket proteins to interact with a multitude of cellular proteins that regulate gene expression at various levels. By regulating gene expression, pocket proteins control cell cycle progression, cell cycle entry and exit, cell differentiation and apoptosis. This review will focus on the mechanisms of regulation of pocket proteins and how modulation of pocket protein levels and phosphorylation status regulate association with their cellular targets. The coordinated regulation of pocket proteins provides the cells with a competence mechanism for passage through certain cell growth and differentiation transitions. |
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| Keywords |
| CDK; CKI; transcriptional regulation; cyclins; cell cycle |
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| 24 December 1998, Volume 17, Number 25, Pages 3365-3383 |
| Table of contents Previous Abstract Next Article PDF |
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