Abstract
The retroviral oncogene v-myb is a mutated and truncated version of the c-myb proto-oncogene and encodes a transcription factor (v-Myb) that specifically transforms myelomonocytic cells. v-Myb is thought to transform myelomonocytic cells by affecting the expression of specific target genes, most of which as yet remain unknown. To identify novel v-Myb regulated genes we have employed `differential display', using a myelomonocytic chicken cell line that expresses a conditional version of v-Myb. Here we describe the identification of the gene encoding the A2b adenosine receptor, a member of the seven transmembrane receptor superfamily, as a v-Myb target gene. Our results provide the first evidence that v-Myb directly regulates a gene encoding a membrane receptor and establish a link between Myb function and adenosine receptor signaling.
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Worpenberg, S., Burk, O. & Klempnauer, KH. The chicken adenosine receptor 2B gene is regulated by v-myb. Oncogene 15, 213–221 (1997). https://doi.org/10.1038/sj.onc.1201179
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DOI: https://doi.org/10.1038/sj.onc.1201179
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