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Peptide partitioning into the lipid bilayer interface can be used as a measure of amino acid hydrophobicity that should be considered in the early stages of membrane protein folding.
The internal core antigen, p24, of HIV performs differing roles at various stages in the viral life cycle. The structure of the protein has now been solved allowing an informed view of its role in isolation and as a domain within the precursor virion structural protein Gag p55.
The crystal structure of ferredoxin from Sulfolobus species strain 7 reveals a novel zinc-binding centre that may play an important role in stabilizing the protein and may be common to thermoacidophilic archaeal ferredoxins.
An aromatic hydrogen bond—an interaction between the π-electron cloud of an aromatic ring and a hydrogen-bond donor—can substitute for a conventional hydrogen bond in sequence-specific protein—DNA interactions and can contribute 0.5–1 kcal mol−1 to binding and 1–2 kcal mol−1 to specificity.
