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Volume 12 Issue 12, December 2005

A Japanese Buddhist temple uses an elaborate system of brackets (cover image) in its architecture. Hamma et al. show that Cbf5 and Nop10, components of the box H/ACA ribonucleoprotein complex involved in pseudouridine modification, have a conserved architecture that may function to organize the secondary structure of the H/ACA RNAs. Photo by R. Reeder. pp 1101-1107

Volume 12 Issue 12

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  • A new study reveals that extracellular signals can activate a signal-transduction cascade that simultaneously alters alternative splicing and translation of the same target. These concerted efforts probably serve to increase the speed and strength of the cellular response to changes in the extracellular environment.

    • Brenton R Graveley
    News & Views

  • Eukaryotic messenger RNAs are degraded through a pathway that starts with the removal of the poly(A) tail. A recent study shows that cytoplasmic mRNA deadenylation in mammals occurs by the consecutive action of two distinct deadenylases and that degradation of nonsense mRNA involves the same biphasic deadenylation pathway.

    • Oliver Mühlemann
    News & Views

  • A new study sheds light on the mechanism regulating the translation of localized mRNAs at their destination. Phosphorylation of an RNA-binding protein by Src promotes complex disassembly and allows translation of the localized transcript.

    • Nicolas Paquin
    • Pascal Chartrand
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  • The induction and repair of chromosome breaks is associated with myriad changes in chromatin. A recent study shows that chromatin remodeling that results in histone eviction at the break site requires the Mre11 complex and INO80 and that these events are important for efficient loading of the Rad51 recombinase.

    • John H J Petrini
    News & Views
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