Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Towards an understanding of amyloidogenesis

Two studies in this issue provide further insight into the structural continuum associated with the process of amyloidosis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic depiction of the structural continuum characterizing the process of amyloid fibril formation from a full length initially folded protein like β2m.

References

  1. McParland, V.J., Kalverda, A.P., Homans, S.W. & Radford, S.E. Nature Struct. Biol. 9, 326–331 (2002).

    Article  CAS  Google Scholar 

  2. Hoshino, M. et al. Nature Struct. Biol. 9, 332–336 (2002).

    Article  CAS  Google Scholar 

  3. Kelly, J.W. Curr. Opin. Struct. Biol. 6, 11–17 (1996).

    Article  CAS  Google Scholar 

  4. Rochet, J.-C. & Lansbury, P.T. Jr Curr. Opin. Struct. Biol. 10, 60–68 (2000).

    Article  CAS  Google Scholar 

  5. Sunde, M. & Blake, C.C.F. Q. Rev. Biophys. 31, 1–39 (1998).

    Article  CAS  Google Scholar 

  6. Dobson, C.M. Trends Biochem. Sci. 24, 329–332 (1999).

    Article  CAS  Google Scholar 

  7. Wetzel, R. Cell 86, 699–702 (1996).

    Article  CAS  Google Scholar 

  8. Kelly, J.W. Curr. Opin. Struct. Biol. 8, 101–106 (1998).

    Article  CAS  Google Scholar 

  9. Pepys, M.B. in Immunological Diseases, Vol. 1 (ed. Samter, M.) 631–674 (Little, Brown & Co., Boston/Toronto, 1988).

    Google Scholar 

  10. Jacobson, D.R. & Buxbaum, J.N. Adv. Hum. Genet. 20, 69–123 (1991).

    Article  CAS  Google Scholar 

  11. Kisilevsky, R. Lab. Invest. 49, 381–390 (1983).

    CAS  PubMed  Google Scholar 

  12. Kisilevsky, R. J. Struct. Biol. 130, 99–108 (2000).

    Article  CAS  Google Scholar 

  13. Selkoe, D.J. Science 275, 630–631 (1997).

    Article  CAS  Google Scholar 

  14. Hammarstrom, P., Schneider, F. & Kelly, J.W. Science 293, 2459–2461 (2001).

    Article  CAS  Google Scholar 

  15. Anderson, O. & Wallin, G. in Second International Symposium On Familial Amyloidotic Polyneuropathy And Other Transthyretin Related Disorders Vol. 1 49 (Skelleftea, Sweden; 1992).

    Google Scholar 

  16. Ando, Y. Rinsho Byori 48, 425–429 (2000).

    CAS  PubMed  Google Scholar 

  17. Coelho, T. Curr. Opin. Neurol. 9, 355–359 (1996).

    Article  CAS  Google Scholar 

  18. Suhr, O.B., Herlenius, G., Friman, S. & Ericzon, B.G. Liver Transp. 6, 263–276. (2000).

    Article  CAS  Google Scholar 

  19. Lamber, M.P. et al. Proc. Natl. Acad. Sci. USA 95, 6448–6453 (1998).

    Article  CAS  Google Scholar 

  20. Snyder, S.W. et al. Biophysical J. 67, 1216–1228 (1994).

    Article  CAS  Google Scholar 

  21. Klein, W.L., Krafft, G.A. & Finch, C.E. Trends Neurosci. 24, 219–224 (2001).

    Article  CAS  Google Scholar 

  22. Harper, J.D., Wong, S.S., Lieber, C.M. & Lansbury, P.T. Jr Chem. Biol. 4, 119–125 (1997).

    Article  CAS  Google Scholar 

  23. Yong, W. et al. Proc. Natl. Acad. Sci. USA 99, 150–154 (2002).

    Article  CAS  Google Scholar 

  24. Ohashi, K. Pathol. Intl. 51, 1–10 (2001).

    Article  CAS  Google Scholar 

  25. Gejyo, F. et al. Biochem. Biophys. Res. Comm. 129, 701–706 (1985).

    Article  CAS  Google Scholar 

  26. Shirahama, T. et al. Lab. Invest. 53, 705–709. (1985).

    CAS  PubMed  Google Scholar 

  27. Connors, L.H., Shirahama, T., Skinner, M., Fenves, A. & Cohen, A.S. Biochem. Biophys. Res. Comm. 131, 1063–1068. (1985).

    Article  CAS  Google Scholar 

  28. Gorevic, P.D. et al. Proc. Natl. Acad. Sci. USA 83, 7908–7912 (1986).

    Article  CAS  Google Scholar 

  29. Colon, W. & Kelly, J.W. Biochemistry 31, 8654–8660 (1992).

    Article  CAS  Google Scholar 

  30. Booth, D.R. et al. Nature 385, 787–793 (1997).

    Article  CAS  Google Scholar 

  31. Hurle, M.R., Helms, L.R., Li, L., Chan, W. & Wetzel, R. Proc. Natl. Acad. Sci. USA 91, 5446–5450 (1994).

    Article  CAS  Google Scholar 

  32. Qu, B.-H., Strickland, E. & Thomas, P.J. J. Biol. Chem. 272, 15739–15744 (1997).

    Article  CAS  Google Scholar 

  33. Chen, C.D. et al. EMBO J. 20, 6277–6287 (2001).

    Article  CAS  Google Scholar 

  34. Kazmirski, S.L. et al. Nature Struct. Biol. 9, 112–116 (2002).

    Article  CAS  Google Scholar 

  35. McParland, V. et al. Biochemistry 39, 8735–8746 (2000).

    Article  CAS  Google Scholar 

  36. Chiti, F. et al. J. Biol. Chem. 276, 46714–46721 (2001).

    Article  CAS  Google Scholar 

  37. Hasebe, Y. Kanazawa Daigaku Juzen Igakkai Zasshi 102, 228–237 (1993).

    CAS  Google Scholar 

  38. Liu, K., Cho, H.S., Lashuel, H.A., Kelly, J.W. & Wemmer, D.E. Nature Struct. Biol. 7, 754–757 (2000).

    Article  CAS  Google Scholar 

  39. Tycko, R. Curr. Opin. Chem. Biol. 4, 500–506 (2000).

    Article  CAS  Google Scholar 

  40. Tycko, R., Antzutkin, O.N., Balbach, J.J. & Reed, J. Polym. Mater. Sci. Eng. 82, 133–134 (2000).

    CAS  Google Scholar 

  41. Benzinger, T.L. et al. Biochemistry 39, 3491–3499 (2000).

    Article  CAS  Google Scholar 

  42. Gregory, D.M. et al. Solid State NMR 13, 149–166 (1998).

    Article  CAS  Google Scholar 

  43. Benzinger, T.L. et al. Proc. Natl. Acad. Sci. USA 95, 13407–13412 (1998).

    Article  CAS  Google Scholar 

  44. Sunde, M. & Blake, C. Adv. Protein Chem. 50, 123–159 (1997).

    Article  CAS  Google Scholar 

  45. Jimenez, J.L. et al. EMBO J. 18, 815–821 (1999).

    Article  CAS  Google Scholar 

  46. Serpell, L.C. et al. J. Mol. Biol. 254, 113–118 (1995).

    Article  CAS  Google Scholar 

  47. Serpell, L.C. et al. J. Mol. Biol. 300, 1033–1039 (2000).

    Article  CAS  Google Scholar 

  48. Kheterpal, I., Zhou, S., Cook, K.D. & Wetzel, R. Proc. Natl. Acad. Sci. USA 97, 13597–13601 (2000).

    Article  CAS  Google Scholar 

  49. Sunde, M. et al. J. Mol. Biol. 273, 729–739 (1997).

    Article  CAS  Google Scholar 

  50. Lynn, D.G. & Meredith, S.C. J. Struct. Biol. 130, 153–173 (2000).

    Article  CAS  Google Scholar 

  51. Blake, C. & Serpell, L. Structure 4, 989–998 (1996).

    Article  CAS  Google Scholar 

  52. Walsh, D.M. et al. Nature 416, 535–539 (2002).

    Article  CAS  Google Scholar 

  53. Bucciantini, M. et al. Nature 416, 507–511 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kelly, J. Towards an understanding of amyloidogenesis. Nat Struct Mol Biol 9, 323–325 (2002). https://doi.org/10.1038/nsb0502-323

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0502-323

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing