The discovery of two unexpected Ca2+-binding sites in the structure of a minimal catalytic domain of μ-calpain reveals a new mechanism underlying the Ca2+-dependent activation of calpains.
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Khorchid, A., Ikura, M. How calpain is activated by calcium. Nat Struct Mol Biol 9, 239–241 (2002). https://doi.org/10.1038/nsb0402-239
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DOI: https://doi.org/10.1038/nsb0402-239
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