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Letter

Nature Structural & Molecular Biology 7, 1117–1120 (1 December 2000) | doi:10.1038/81964

Point mutations alter the mechanical stability of immunoglobulin modules

Hongbin Li , Mariano Carrion-Vazquez , Andres F. Oberhauser , Piotr E. Marszalek & Julio M. Fernandez

Immunoglobulin-like modules are common components of proteins that play mechanical roles in cells such as muscle elasticity and cell adhesion. Mutations in these proteins may affect their mechanical stability and thus may compromise their function.