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Protein unfolding: mitochondria offer a helping hand

Nature Structural Biology volume 6, pages 1084–1085 (1999)Cite this article

Abstract

Post-translocational protein import into mitochondria requires that the protein be unfolded prior to import. Mapping the mitochondrial-assisted unfolding pathway of a cargo protein and demonstrating that it deviates from the spontaneous unfolding pathway have provided valuable insight into the energetics of the translocation process.

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Figure 1: Alteration of the protein unfolding pathway by mitochondria.

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Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, 01003, MA, USA

    Daniel N. Hebert

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  1. Daniel N. Hebert
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Hebert, D. Protein unfolding: mitochondria offer a helping hand. Nat Struct Mol Biol 6, 1084–1085 (1999). https://doi.org/10.1038/70006

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