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Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

Nature Structural Biology volume 4, pages 605–608 (1997)Cite this article

The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

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Author notes

  1. Deborah S. Wuttke

    Present address: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, 80309, USA

  2. Mark P. Foster and Deborah S. Wuttke: These authors contributed equally to this research.

Authors and Affiliations

  1. Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA

    Mark P. Foster, Deborah S. Wuttke, Ishwar Radhakrishnan & Peter E. Wright

  2. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA

    David A. Case & Joel M. Gottesfeld

Authors
  1. Mark P. Foster
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Correspondence to Peter E. Wright.

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Foster, M., Wuttke, D., Radhakrishnan, I. et al. Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA. Nat Struct Mol Biol 4, 605–608 (1997). https://doi.org/10.1038/nsb0897-605

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