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Crystal structure of turnip yellow mosaic virus

Nature Structural Biology volume 3, pages 771–781 (1996)Cite this article

Abstract

The structure of turnip yellow mosaic virus (TYMV) has been solved to 3.2 Å resolution and an R-value of 18.7%. The structure is consistent with models based on low resolution X-ray and electron microscopy studies, with pentameric and hexameric protein aggregates protruding from the surface and forming deep valleys at the quasi three-fold axes. The N-terminal 26 residues of the A-subunit are disordered, while those of the B- and C-subunits are seen to interact around the interior of the quasi six-fold cluster where they form an annulus. The three histidine residues of each protein subunit are located in the interior and accessible for interaction with the RNA genome. The appearance of the interior surface of the virus capsid, along with buried surface area calculations, suggest that a pentameric unit is lost during decapsidation.

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  1. Department of Biochemistry, University of California, Riverside, California, 92521, USA

    Mary A. Canady, Steven B. Larson, John Day & Alexander McPherson

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Canady, M., Larson, S., Day, J. et al. Crystal structure of turnip yellow mosaic virus. Nat Struct Mol Biol 3, 771–781 (1996). https://doi.org/10.1038/nsb0996-771

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