Dynamic supercoiling is a steady-state mechanical regulatory mechanism that influences DNA topology, transcription factor binding, gene expression, chromatin structure and long-range chromosome interactions. How genes and nongene regions are organized into supercoiled domains and remodeled by transcriptional activity in human cells has now been analyzed in two large-scale studies at the chromosome and genome levels, providing new insight into the organization and expression of genes within chromosomes.
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Sinden, R. The helix turns at 60: writhing free in chromosomes. Nat Struct Mol Biol 20, 251–253 (2013). https://doi.org/10.1038/nsmb.2533
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DOI: https://doi.org/10.1038/nsmb.2533
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