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Commentary

Nature Structural & Molecular Biology 16, 678–680 (1 July 2009) | doi:10.1038/nsmb0709-678

WDR5, a complexed protein

Raymond C Trievel & Ali Shilatifard

The yeast Saccharomyces cerevisiae complex COMPASS, containing Set1 and seven other polypeptides (Fig. 1), was the first histone H3K4 methylase (KMT) to be identified.