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Sister chromatids caught in the cohesin trap

Nature Structural & Molecular Biology volume 15, pages 899–900 (2008)Cite this article

Cohesin is a large ring-shaped protein complex that mediates cohesion between sister chromatids. New experiments show that the sister chromatids of a minichromosome are entrapped by monomeric cohesin rings, thus excluding the possibility that sister chromatid cohesion is mediated by nontopological interactions between cohesin complexes.

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Figure 1: Covalently closed cohesin rings hold minichromosome chromatids together after protein denaturation.

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Acknowledgements

This work was supported by Austrian Science Fund grants (P18955, P20444, F3403) and the (European Community's) Seventh Framework Programme (FP7/2007-2013) under grant agreement number PIEF-GA-2008-220518.

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Authors and Affiliations

  1. Department of Chromosome Biology, Lubos Cipak, Mario Spirek and Juraj Gregan are in the Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 1, 1030 Vienna, Austria. juraj.gregan@univie.ac.at,

    Lubos Cipak, Mario Spirek & Juraj Gregan

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Cipak, L., Spirek, M. & Gregan, J. Sister chromatids caught in the cohesin trap. Nat Struct Mol Biol 15, 899–900 (2008). https://doi.org/10.1038/nsmb0908-899

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