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When a domain is not a domain

Nature Structural & Molecular Biology volume 15, pages 224–226 (2008)Cite this article

The kinase regulatory-loop binding (KRLB) region of insulin receptor substrate 2 was originally thought to be a new type of domain with binding properties similar to phosphotyrosine binding (PTB) domains. A crystallographic study now shows that KRLB is actually a short peptide segment that binds to the insulin receptor using an extended series of contacts that mimic both autoinhibitory loop and ATP binding to its catalytic cleft.

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Figure 1: Schematic representations of insulin receptor–IRS2 interactions and activation states.

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Authors and Affiliations

  1. Sang Youn Park and Steven E. Shoelson are at the Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. steven.shoelson@joslin.harvard.edu,

    Sang Youn Park & Steven E Shoelson

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  1. Sang Youn Park
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  2. Steven E Shoelson
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Park, S., Shoelson, S. When a domain is not a domain. Nat Struct Mol Biol 15, 224–226 (2008). https://doi.org/10.1038/nsmb0308-224

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