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Brief Communication

Nature Structural & Molecular Biology 14, 349–350 (1 April 2007) | doi:10.1038/nsmb1220

The 3|[prime]| termini of mouse Piwi-interacting RNAs are 2|[prime]|-O-methylated

Tomoya Ohara , Yuriko Sakaguchi , Takeo Suzuki , Hiroki Ueda , Kenjyo Miyauchi & Tsutomu Suzuki

Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs.