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Nature Structural & Molecular Biology 14, 261 - 262 (2007)
doi:10.1038/nsmb0407-261
La sets the tone for telomerase assembly
M Teresa Teixeira1 & Eric Gilson1
- M. Teresa Teixeira and Eric Gilson are in the Laboratory of Molecular Cell Biology, Ecole Normale Supérieure de Lyon, CNRS UMR 5239, IFR128, 46 Allée d'Italie, 69364 Lyon cedex 07, France. e-mail: eric.gilson@ens-lyon.fr
Abstract
The functional assembly of a ciliate telomerase requires ordered RNA conformational changes mediated by a La motif–containing protein. This raises new questions about telomerase biogenesis and the evolutionary origin of the telomerase RNA.
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