Brief Communication abstract
Nature Structural & Molecular Biology 14, 243 - 245 (2007)
Published online: 18 February 2007 | doi:10.1038/nsmb1204
There is an Erratum (April 2007) associated with this Brief Communication.
Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase
Gaoyang Liang1,2, Robert J Klose1,2, Kathryn E Gardner1 & Yi Zhang1
Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain–containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.
- Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.
- These authors contributed equally to this work.
Correspondence to: Yi Zhang1 e-mail: yi_zhang@med.unc.edu
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