Table of contents
November 2007, Volume 14 No 11 pp985-1115
About the coverFocus
Focus on Chromatin
- Focus issue:
- November 2007 Volume 14, No 11
In eukaryotes, the packaging of DNA by histones into chromatin has profound effects on transcription and other nuclear processes. Far from being a uniform set of 'beads on a string', chromatin structure is remodeled and even modified, altering the accessibility of packaged genes to the factors involved in their regulation. This special focus on chromatin features an Overview, six Reviews and a Perspective that describe how chromatin is built and subsequently altered at various structural levels, and the impact of these events on fundamental biological processes involving DNA.
Editorial
Focus on Chromatin
Chromatin coming into focus - p985
doi:10.1038/nsmb1107-985
Full Text - Chromatin coming into focus | PDF (232 KB) - Chromatin coming into focus
Overview
Focus on Chromatin
Chromatin rules - pp986 - 988
Roger D Kornberg & Yahli Lorch
doi:10.1038/nsmb1107-986
Full Text - Chromatin rules | PDF (306 KB) - Chromatin rules
Perspective
Focus on Chromatin
Chromatin remodeling: insights and intrigue from single-molecule studies - pp989 - 996
Bradley R Cairns
doi:10.1038/nsmb1333
Abstract - Chromatin remodeling: insights and intrigue from single-molecule studies | Full Text - Chromatin remodeling: insights and intrigue from single-molecule studies | PDF (1,109 KB) - Chromatin remodeling: insights and intrigue from single-molecule studies
Reviews
Focus on Chromatin
Histone chaperones: an escort network regulating histone traffic - pp997 - 1007
Leanne De Koning, Armelle Corpet, James E Haber & Geneviève Almouzni
doi:10.1038/nsmb1318
Abstract - Histone chaperones: an escort network regulating histone traffic | Full Text - Histone chaperones: an escort network regulating histone traffic | PDF (931 KB) - Histone chaperones: an escort network regulating histone traffic
Focus on Chromatin
Covalent modifications of histones during development and disease pathogenesis - pp1008 - 1016
Sukesh R Bhaumik, Edwin Smith & Ali Shilatifard
doi:10.1038/nsmb1337
Abstract - Covalent modifications of histones during development and disease pathogenesis | Full Text - Covalent modifications of histones during development and disease pathogenesis | PDF (1,330 KB) - Covalent modifications of histones during development and disease pathogenesis
Focus on Chromatin
Cross-regulation of histone modifications - pp1017 - 1024
John A Latham & Sharon Y R Dent
doi:10.1038/nsmb1307
Abstract - Cross-regulation of histone modifications | Full Text - Cross-regulation of histone modifications | PDF (504 KB) - Cross-regulation of histone modifications
Focus on Chromatin
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers - pp1025 - 1040
Sean D Taverna, Haitao Li, Alexander J Ruthenburg, C David Allis & Dinshaw J Patel
doi:10.1038/nsmb1338
Abstract - How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers | Full Text - How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers | PDF (2,286 KB) - How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers | Supplementary information
Focus on Chromatin
Transcription and RNAi in heterochromatic gene silencing - pp1041 - 1048
Marc Bühler & Danesh Moazed
doi:10.1038/nsmb1315
Abstract - Transcription and RNAi in heterochromatic gene silencing | Full Text - Transcription and RNAi in heterochromatic gene silencing | PDF (675 KB) - Transcription and RNAi in heterochromatic gene silencing
Focus on Chromatin
Gene regulation through nuclear organization - pp1049 - 1055
Tom Sexton, Heiko Schober, Peter Fraser & Susan M Gasser
doi:10.1038/nsmb1324
Abstract - Gene regulation through nuclear organization | Full Text - Gene regulation through nuclear organization | PDF (1,213 KB) - Gene regulation through nuclear organization
News and Views
Chromatin structure depends on what's in the nucleosome's pocket - pp1056 - 1058
Tamara L Caterino & Jeffrey J Hayes
doi:10.1038/nsmb1107-1056
Full Text - Chromatin structure depends on what's in the nucleosome's pocket | PDF (1,211 KB) - Chromatin structure depends on what's in the nucleosome's pocket
See also: Article by Zhou et al. | Brief Communication by Chodaparambil et al.
Histone H3 Arg2 methylation provides alternative directions for COMPASS - pp1058 - 1060
Robert J Klose & Yi Zhang
doi:10.1038/nsmb1107-1058
Full Text - Histone H3 Arg2 methylation provides alternative directions for COMPASS | PDF (254 KB) - Histone H3 Arg2 methylation provides alternative directions for COMPASS
Research Highlights - p1061
doi:10.1038/nsmb1107-1061
Full Text - Research Highlights | PDF (122 KB) - Research Highlights
Articles
Molecular driving forces determining potassium channel slow inactivation - pp1062 - 1069
Julio F Cordero-Morales, Vishwanath Jogini, Anthony Lewis, Valeria Vásquez, D Marien Cortes, Benoît Roux & Eduardo Perozo
doi:10.1038/nsmb1309
Abstract - Molecular driving forces determining potassium channel slow inactivation | Full Text - Molecular driving forces determining potassium channel slow inactivation | PDF (817 KB) - Molecular driving forces determining potassium channel slow inactivation | Supplementary information
The nucleosome surface regulates chromatin compaction and couples it with transcriptional repression - pp1070 - 1076
Jiansheng Zhou, Jun Y Fan, Danny Rangasamy & David J Tremethick
doi:10.1038/nsmb1323
Abstract - The nucleosome surface regulates chromatin compaction and couples it with transcriptional repression | Full Text - The nucleosome surface regulates chromatin compaction and couples it with transcriptional repression | PDF (498 KB) - The nucleosome surface regulates chromatin compaction and couples it with transcriptional repression | Supplementary information
See also: News and Views by Caterino & Hayes
prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast - pp1077 - 1083
Kum-Loong Boon, Richard J Grainger, Parastoo Ehsani, J David Barrass, Tatsiana Auchynnikava, Chris F Inglehearn & Jean D Beggs
doi:10.1038/nsmb1303
Abstract - prp8: mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast | Full Text - prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast | PDF (479 KB) - prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast | Supplementary information
Autonomous synchronization of the circadian KaiC phosphorylation rhythm - pp1084 - 1088
Hiroshi Ito, Hakuto Kageyama, Michinori Mutsuda, Masato Nakajima, Tokitaka Oyama & Takao Kondo
doi:10.1038/nsmb1312
Abstract - Autonomous synchronization of the circadian KaiC phosphorylation rhythm | Full Text - Autonomous synchronization of the circadian KaiC phosphorylation rhythm | PDF (572 KB) - Autonomous synchronization of the circadian KaiC phosphorylation rhythm | Supplementary information
Conformational dynamics of the KcsA potassium channel governs gating properties - pp1089 - 1095
Kent A Baker, Christos Tzitzilonis, Witek Kwiatkowski, Senyon Choe & Roland Riek
doi:10.1038/nsmb1311
Abstract - Conformational dynamics of the KcsA potassium channel governs gating properties | Full Text - Conformational dynamics of the KcsA potassium channel governs gating properties | PDF (591 KB) - Conformational dynamics of the KcsA potassium channel governs gating properties | Supplementary information
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks - pp1096 - 1104
Katsuhiro Hanada, Magda Budzowska, Sally L Davies, Ellen van Drunen, Hideo Onizawa, H Berna Beverloo, Alex Maas, Jeroen Essers, Ian D Hickson & Roland Kanaar
doi:10.1038/nsmb1313
Abstract - The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks | Full Text - The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks | PDF (610 KB) - The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks | Supplementary information
Brief Communications
A charged and contoured surface on the nucleosome regulates chromatin compaction - pp1105 - 1107
Jayanth V Chodaparambil, Andrew J Barbera, Xu Lu, Kenneth M Kaye, Jeffrey C Hansen & Karolin Luger
doi:10.1038/nsmb1334
Abstract - A charged and contoured surface on the nucleosome regulates chromatin compaction | Full Text - A charged and contoured surface on the nucleosome regulates chromatin compaction | PDF (320 KB) - A charged and contoured surface on the nucleosome regulates chromatin compaction | Supplementary information
See also: News and Views by Caterino & Hayes
Structural insight into OprD substrate specificity - pp1108 - 1109
Shyamasri Biswas, Mohammad M Mohammad, Dimki R Patel, Liviu Movileanu & Bert van den Berg
doi:10.1038/nsmb1304
Abstract - Structural insight into OprD substrate specificity | Full Text - Structural insight into OprD substrate specificity | PDF (518 KB) - Structural insight into OprD substrate specificity | Supplementary information
Primers
Focus on Chromatin
Primers on chromatin - pp1110 - 1115
Sabbi Lall
doi:10.1038/nsmb1107-1110
Abstract - Primers on chromatin | Full Text - Primers on chromatin | PDF (6,377 KB) - Primers on chromatin
