Post-translational modification of histones can profoundly affect chromatin structure and function. The discovery that histone H3 Arg2 methylation is a widespread silencing modification that inhibits histone H3 Lys4 trimethylation extends our understanding of how active and silenced chromatin states are maintained.
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Klose, R., Zhang, Y. Histone H3 Arg2 methylation provides alternative directions for COMPASS. Nat Struct Mol Biol 14, 1058–1060 (2007). https://doi.org/10.1038/nsmb1107-1058
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DOI: https://doi.org/10.1038/nsmb1107-1058
