MicroRNAs (miRNAs) are noncoding small RNAs thought to post-transcriptionally regulate many metazoan genes by binding to partially complementary sites in target messenger RNAs. In this issue, Didiano and Hobert examine known and predicted targets of the nematode lsy-6 miRNA, question the general validity of previously proposed rules about miRNA-target interactions and suggest that many functional miRNA targets might be context dependent, as seen in metazoan gene regulation by transcription factors.
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Acknowledgements
I would like to thank S. Small, F. Piano and K. Gunsalus for helpful discussions and F. Piano and K. Gunsalus for critical comments on the manuscript.
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Rajewsky, N. L(ou)sy miRNA targets?. Nat Struct Mol Biol 13, 754–755 (2006). https://doi.org/10.1038/nsmb0906-754
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DOI: https://doi.org/10.1038/nsmb0906-754
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