This year's Nobel laureate in chemistry is Roger Kornberg. Patrick Cramer gives a personal account of how the Kornberg laboratory determined the structure of the RNA polymerase II core enzyme.
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References
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Acknowledgements
I thank my wife for all her support. I apologize to colleagues who helped with the project but who could not be mentioned owing to space constraints. I also apologize to colleagues whose work could not be cited because of the special focus of this essay. I thank M. Bertero for critical reading of the manuscript.
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Cramer, P. Deciphering the RNA polymerase II structure: a personal perspective. Nat Struct Mol Biol 13, 1042–1044 (2006). https://doi.org/10.1038/nsmb1206-1042
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DOI: https://doi.org/10.1038/nsmb1206-1042