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Reeling in the bases

Nature Structural & Molecular Biology volume 11, pages 804–806 (2004)Cite this article

EcoR124I is a type I DNA restriction and modification enzyme. The single-molecule magnetic tweezers technique reveals that this sophisticated molecular machine is capable of moving thousands of base pairs of DNA in one binding event.

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Figure 1: Action of the type I and type II restriction enzymes on DNA.

References

  1. Bertani, G. & Weigle, J.J. J. Bacteriol. 65, 113–121 (1953).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Arber, W. & Dussoix, D. J. Mol. Biol. 5, 18–36 (1962).

    Article  CAS  Google Scholar 

  3. Meselson, M. & Yuan, R. Nature 217, 1110–1114 (1968).

    Article  CAS  Google Scholar 

  4. Watson, J.D. & Crick, F.H. Nature 171, 737–738 (1953).

    Article  CAS  Google Scholar 

  5. Kelly, T.J. Jr. & Smith, H.O. J. Mol. Biol. 51, 393–409 (1970).

    Article  CAS  Google Scholar 

  6. Roberts, R.J., Vincze, T., Posfai, J. & Macelis, D. Nucleic Acids Res. 31, 418–420 (2003).

    Article  CAS  Google Scholar 

  7. Murray, N.E. Microbiol. Mol. Biol. Rev. 64, 412–434 (2000).

    Article  CAS  Google Scholar 

  8. Bourniquel, A.A. & Bickle, T.A. Biochimie 84, 1047–1059 (2002).

    Article  CAS  Google Scholar 

  9. Seidel, R. et al. Nat. Struct. Mol. Biol. 11, 838–843 (2004).

    Article  CAS  Google Scholar 

  10. Allemand, J.F., Bensimon, D. & Croquette, V. Curr. Opin. Struct. Biol. 13, 266–274 (2003).

    Article  CAS  Google Scholar 

  11. Yuan, R., Hamilton, D.L. & Burckhardt, J. Cell 20, 237–244 (1980).

    Article  CAS  Google Scholar 

  12. Studier, F.W. & Bandyopadhyay, P.K. Proc. Natl. Acad. Sci. USA 85, 4677–4681 (1988).

    Article  CAS  Google Scholar 

  13. Janscak, P., MacWilliams, M.P., Sandmeier, U., Nagaraja, V. & Bickle, T.A. EMBO J. 18, 2638–2647 (1999).

    Article  CAS  Google Scholar 

  14. Garcia, L.R. & Molineux, I.J. Proc. Natl. Acad. Sci. USA 96, 12430–12435 (1999).

    Article  CAS  Google Scholar 

  15. Firman, K. & Szczelkun, M.D. EMBO J. 19, 2094–2102 (2000).

    Article  CAS  Google Scholar 

  16. Dryden, D.T.F., Cooper, L.P., Thorpe, P.H. & Byron, O. Biochemistry 36, 1065–1076 (1997).

    Article  CAS  Google Scholar 

  17. Halford, S.E., Welsh, A.J. & Szczelkun, M.D. Annu. Rev. Biophys. Biomol. Struct. 33, 1–24 (2004).

    Article  CAS  Google Scholar 

  18. Singleton, M.R. & Wigley, D.B. J. Bacteriol. 184, 1819–1826 (2002).

    Article  CAS  Google Scholar 

  19. Davies, G.P. et al. J. Mol. Biol. 290, 565–579 (1999).

    Article  CAS  Google Scholar 

Download references

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  1. School of Chemistry, The University of Edinburgh, The King's Buildings, Edinburgh, EH9 3JJ, UK

    David T F Dryden

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  1. David T F Dryden
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Dryden, D. Reeling in the bases. Nat Struct Mol Biol 11, 804–806 (2004). https://doi.org/10.1038/nsmb0904-804

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