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In this Review, the authors discuss the various ways that alternative splicing sculpts the landscape of protein interactions with their partners, essentially all types of biomolecules, and the implications of alternative interactions at the molecular, cellular and disease level.
The Review provides an overview of ion-channel insecticide targets, with a focus on their mechanisms of action, and offers a perspective for structure-based development of insecticides.
In this Review, the authors present and discuss the mechanistic and functional implications of new cryo-EM structures of telomerase from different species, contextualizing the new insights in light of existing functional analyses and decades-long hypotheses and conundrums.
Here, the authors describe the composition, architecture, functions and mechanisms of the SMC (structural maintenance of chromosomes) complex Smc5/6 in chromosomal replication and repair, as well as its involvement in disease.
In this Review, the authors provide a comprehensive overview of recent structural studies of the cGAS–STING complex, discussing pertinent functional and mechanistic implications.