Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Putting a lid on it

A cap at the tip of the bacterial flagellum uses a dynamic differential binding of individual subunits to allow the filament tip to grow, achieving control of assembly far from the point of protein translation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: a, The structure of the bacterial flagellum is composed of three parts.
Figure 2: At the distal end of the bacterial flagellum, the five flexible leg domains of the planar cap attach to the cap at the distal end of the polymerizing filament.

References

  1. Yonekura, K. et al. Science 290, 2148–2152 (2000).

    Article  CAS  Google Scholar 

  2. Macnab, R.M. In Escherichia coli and Salmonella typhimurium: cellular and molecular biology (eds Neidhart, F.C. et al.) 123–145 (American Society for Microbiology, Washington, D.C.; 1996).

    Google Scholar 

  3. Berg, H.C. Biophys. J. 68, 163S–167S (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Berry, R.M. & Armitage, J.P. Adv. Microb. Physiol. 41, 291–337 (1999).

    Article  CAS  Google Scholar 

  5. DeRosier, D.J. Cell 93, 17–20 (1998).

    Article  CAS  Google Scholar 

  6. Blair, D.F. Annu. Rev. Microbiol. 49, 489–522 (1995).

    Article  CAS  Google Scholar 

  7. Stock, J.B. & Surette, M.S. In Escherichia coli and Salmonella typhimurium: cellular and molecular biology (eds Neidhart, F.C. et al.) 1103–1129 (American Society for Microbiology, Washington, D.C.; 1996).

    Google Scholar 

  8. Aizawa, S.-I. Mol. Microbiol. 20, 1–4. (1996).

    Article  Google Scholar 

  9. Macnab, R.M.T. J. Bacteriol. 181, 149–153 (1999).

    Google Scholar 

  10. Morgan, D.G., Owen, C., Melanson, L.A. & DeRosier, D.J. J. Mol. Biol. 249, 88–110 (1995).

    Article  CAS  Google Scholar 

  11. Asakura, S. G. E. & Iino, T. J. Mol. Biol. 35, 227–236 (1968).

    Article  CAS  Google Scholar 

  12. Homma, M. & Iino, T. J. Bacteriol. 162, 183–189 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Homma, M. & Iino, T. J. Bacteriol. 164, 1370–1372 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Hughes, K.T., Gillen, K.L., Semon, M.J. & Karlinsey, J.E. Science 262, 1277–1280 (1993).

    Article  CAS  Google Scholar 

  15. Kutsukake, K. Mol. Gen. Genet. 243, 605–612 (1994).

    CAS  PubMed  Google Scholar 

  16. Imada, K., Vonderviszt, F., Furukawa, Y., Oosawa, K. & Namba, K. J. Mol. Biol. 277, 883–891 (1998).

    Article  CAS  Google Scholar 

  17. Vonderviszt, F. et al. J. Mol. Biol. 284, 1399–1416 (1998).

    Article  CAS  Google Scholar 

  18. Maki, S., Vonderviszt, F., Furukawa, Y., Imada, K. & Namba, K. J. Mol. Biol. 277, 771–777 (1998).

    Article  CAS  Google Scholar 

  19. Homma, M., Fujita, H., Yamaguchi, S. & Iino, T. J. Bacteriol. 159, 1056–1059 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Homma, M., Iino, T., Kutsukake, K. & Yamaguchi, S. Proc. Natl. Acad. Sci. U S A 83, 6169–6173 (1986).

    Article  CAS  Google Scholar 

  21. Ikeda, T., Yamaguchi, S. & Hotani, H. J. Biochem. (Tokyo) 114, 39–44 (1993).

    Article  CAS  Google Scholar 

  22. Trachtenberg, S. & DeRosier, D.J. J. Mol. Biol. 195, 581–601 (1987).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kelly T. Hughes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hughes, K., Aldridge, P. Putting a lid on it. Nat Struct Mol Biol 8, 96–97 (2001). https://doi.org/10.1038/84194

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/84194

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing