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Surveys show that both men and their female partners are interested in a 'male pill'. A near-unanimous majority of women in stable relationships would trust their partner to assume responsibility for contraception. The results of a Chinese multicenter, phase III trial of monthly testosterone injections bring us a step closer to making this great leap forward.
Patients with pT3N0M0 disease after radical prostatectomy for localized prostate cancer are at risk for local relapse. Immediate radiation therapy is known to improve local control and biochemical disease-free survival in these individuals. What effect, then, does it have on metastasis and overall survival?
The South European Uroncological Group has conducted a phase III trial comparing intermittent androgen deprivation with continuous therapy in patients with advanced prostate cancer. The intermittent regimen was found to be non-inferior in terms of disease progression, survival, and quality of life. Nevertheless, the implications of such research for patient management remain controversial.
Erectile dysfunction following radical prostatectomy is common in men recovering from prostate cancer. The authors of this Review discuss the measures that can be taken to help preserve erectile function in men undergoing this surgery and approaches to treating men with postprostatectomy erectile dysfunction, including the concept of penile rehabilitation.
The discovery of recurrent ETS gene fusions in prostate cancer has improved our understanding of prostate carcinogenesis and suggests novel targets for therapy. Here, Clark and Cooper discuss the variety of ETS gene fusions and their role in prostate cancer development, and outline the prognostic and therapeutic implications of this knowledge.
Stent-related symptoms are the cause of considerable morbidity for patients who undergo urological procedures. Here, Chew and Lange describe how urologists can limit the complications of stent placement, focusing on the ongoing development of stent technology to prevent bacterial adhesion and infection.
This Case Study discusses the management of a female neonate in whom a large pelvic mass had been detected 9 weeks before birth. She was diagnosed with botryoid rhabdomyosarcoma of the bladder. Tumor eradication was achieved with chemotherapy alone, and she remained free from recurrence during 24 months of follow-up.
Alternative splicing has been proposed as a key contributor to the genetic diversity observed in prostate tumors. Here, the authors focus on the clinically relevant consequences of alternative splicing in prostate cancer, and describe how cancer-specific splicing events may be exploited as novel biomarkers and therapeutic targets for individualized care of patients.
