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In this Viewpoint article by Pelzer and Horninger, the authors describe a screening strategy for preventing the underdiagnosis of clinically relevant prostate cancer and the overdiagnosis of clinically insignificant disease. The authors argue that the ultimate goal of screening should be to detect biologically consequential disease sufficiently early to allow treatment for cure.
This Viewpoint article by Siddiqi and Lewis discusses the role of surgical therapy for the treatment of erectile dysfunction. The article explains why surgical therapy will likely always remain an option for specific patients, regardless of whether or not gene therapy is approved for erectile dysfunction treatment.
Sling techniques to treat female urinary stress incontinence began as invasive reappropriations of muscle. This therapy has, however, evolved into a safe and efficacious approach, for which many types of synthetic sling are now commercially available, each with its own particular characteristics. This Review tracks the evolution of this therapy and discusses current outcomes.
As the requirement for organs by patients with end-stage renal disease outstrips the size of the donor pool, new sources for kidney donations must be sought. In this Review, the authors discuss the medical, surgical and particularly the psychosocial features of programs aimed at expanding the availability of living donations.
Men with lower urinary tract symptoms frequently do not seek medical advice. For those who do, the traditional view of a solely prostatic origin might hinder management, since growing evidence suggests an important role for nonprostatic causes. This Review clarifies terminology for symptoms and causes and presents an overview of the available medical therapies.
In this Case Study, Subramanian et al. present a patient who underwent orchiectomy for low-stage nonseminomatous germ cell tumor of the testis. The patient opted for management by surveillance, and subsequently developed a recurrent teratoma of the spermatic cord. The case illustrates the importance of combining imaging and tumor marker measurement in surveillance protocols.
The iliac-artery–ureteral fistula is a rare, but potentially lethal entity. In this Case Study by Gallo et al. the case of a 66-year-old man who presented with hematuria is used to illustrate the successful diagnosis and management of this condition using only endoscopic techniques.
