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Although oral phosphodiesterase 5 inhibitors have substantially improved the treatment of erectile dysfunction, unmet needs among men with erectile dysfunction still exist. This article considers the possibility of gene therapy for these patients, and discusses results from early clinical studies of gene therapy for erectile dysfunction.
The use of nomograms for predicting tumor characteristics and outcomes in prostate cancer patients can be helpful in treatment decision-making. In this article the authors review several nomograms, developed since the observed stage migration in prostate cancer, that can be used to predict cancer prevalence at prostate biopsy, prognosis and pretreatment staging.
Ejaculatory dysfunction is a common and distressing problem for many men, which can adversely affect their personal relationships and quality of life. In this Review the authors discuss the physiopathological, diagnostic, and therapeutic aspects of disorders of ejaculation focusing on premature ejaculation, the most prevalent of these disorders.
Balkan endemic nephropathy is a familial disorder that affects people living in the alluvial plains along the tributaries of the Danube River and has a strong association with upper urothelial carcinomas. Although thought to be declining in incidence, it still represents a notable problem and these authors suggest it might be more widespread than previously thought.
In this Case Study, Phipps et al. describe a 33-year-old woman with severe hypertension resulting from iatrogenic ureteric injury. The authors discuss the underlying mechanisms of hypertension caused by ureteric obstruction, and they use the case to illustrate the effective endourological management of short, completely obliterating, distal ureteric strictures.
