Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
New research has shown that African American men have a significantly higher rate of non-organ-confined prostate cancers than their white counterparts. Is now the time to finally consider changing the criteria for active surveillance based on ethnic risk?
Testicular germ cell tumours are the most common malignancy in young adult males. Recent data suggest that the predominant histological subtype appears to be shifting towards seminomas, which is mirrored in an increasing age at presentation. However, as nonseminomatous tumours present earlier, recent declines in its incidence might be more informative of overall trends.
Current biopsy techniques and clinical disease assessment of prostate cancer frequently fail to accurately stratify men according to risk. Recent advances in biopsy techniques, imaging, molecular genetics, and biomarkers could enable physicians to improve risk stratification at the individual level, thereby improving patient management for prostate cancer.
In this Review, Hsu and colleagues discuss the reported effects of oestrogens, anti-oestrogens, and oestrogen receptors on bladder cancer development, growth, and invasion in cell and mouse cancer models, as well as in the clinical setting.
Methylated genes have been proposed as diagnostic and prognostic biomarkers for patients with both muscle-invasive and non-muscle-invasive bladder cancer. In this Review, the authors describe the body of evidence on gene methylation and the associations with progression, recurrence and survival, which might contribute to clinical decision-making and individualized treatment.
In this Review, Wettersten and Weiss discuss novel urinary and blood biomarkers and therapeutic targets for renal cell carcinoma, with the hope that dissemination of this information might lead to clinical utilization.
Although technical advances have enabled the delivery of precise radiotherapeutic doses to prostate tumours, reducing the dose given to surrounding tissues, radiotherapy-associated toxicity can not be completely avoided. This Review describes the possible methods to reduce late rectal injury as well as the patient-specific characteristics that the radio-oncologist should consider.
In this Perspectives article, the author presents his theory that pressure has shaped the morphology of the prostate over time, and discusses the implications this might have on the longstanding debate of the relationship between BPH and prostate cancer.
