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  • Case Study
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A case of T2 muscle-invasive bladder cancer treated with neoadjuvant chemotherapy

Nature Clinical Practice Urology volume 3, pages 675–679 (2006)Cite this article

Abstract

Background A 61-year-old woman with a substantial history of smoking presented with gross hematuria. Cystoscopic evaluation revealed a large bladder tumor.

Investigations Cystoscopic evaluation, histological examination, crosssectional imaging.

Diagnosis High-grade muscle-invasive transitional cell carcinoma (clinical stage T2N0M0, later confirmed as pathologic stage T3aN0M0).

Management Transurethral resection of the bladder tumor, clinical trialbased neoadjuvant treatment with paclitaxel, carboplatin and gemcitabine, and radical cystectomy.

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Figure 1: Survival according to treatment group and complete pathologic response (pT0) in patients treated with either neoadjuvant MVAC and cystectomy or cystectomy alone.
Figure 2: Hazard ratios for subgroups classified according to T stage, gender, and age.
Figure 3: Overall survival in patients with clinical T2 disease.
Figure 4: Survival according to treatment group and stage in patients treated with either neoadjuvant chemotherapy (MVAC) and cystectomy or cystectomy alone.

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Authors and Affiliations

  1. Urologic Oncology in the Department of Urology at the University of Michigan, MI

    Scott M Gilbert & Cheryl T Lee

  2. Urology at the University of Michigan, MI, USA

    Scott M Gilbert & Cheryl T Lee

  3. Bladder Cancer Research Program,

    Scott M Gilbert & Cheryl T Lee

Authors
  1. Scott M Gilbert
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  2. Cheryl T Lee
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Corresponding author

Correspondence to Cheryl T Lee.

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The authors declare no competing financial interests.

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Gilbert, S., Lee, C. A case of T2 muscle-invasive bladder cancer treated with neoadjuvant chemotherapy. Nat Rev Urol 3, 675–679 (2006). https://doi.org/10.1038/ncpuro0655

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  • DOI: https://doi.org/10.1038/ncpuro0655

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