10-year data from the European Organisation for Research and Treatment of Cancer trial 22911 have been published, reigniting the debate regarding postoperative radiotherapy for prostate cancer. These data show that adjuvant radiotherapy significantly improves biochemical progression-free survival and local control compared with a 'wait-and-see' policy, supporting the 5-year follow-up data.
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References
Bolla, M. et al. Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). Lancet 366, 572–578 (2005).
van der Kwast, T. et al. Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911. J. Clin. Oncol. 25, 4178–4186 (2007).
Thompson, I. M. et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized trial. JAMA 296, 2329–2335 (2006).
Wiegel, T. et al. Phase III postoperative adjuvant radiotherapy after radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate specific antigen: ARO 96–02/AUO AP 09/95. J. Clin. Oncol. 27, 2924–2930 (2009).
Trabulsi, E. J. et al. A multi-institutional matched-control analysis of adjuvant and salvage postoperative radiation therapy for pT3–4N03. Urology 72, 1298–1304 (2008).
Ghadjar, P., Zwahlen, D., Aebersold, D. M. & Zimmermann, F. Postoperative radiotherapy after radical prostatectomy: indications and open questions. Prostate Cancer http://dx.doi.org/10.1155/2012/963417.
Detti, B. et al. Adjuvant and salvage radiotherapy after prostatectomy: outcome analysis of 307 patients with prostate cancer. J. Cancer Res. Clin. Oncol. http://dx.doi.org/10.1007/s00432-012-1309-9.
Bolla, M. et al. Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomized controlled trial (EORTC trial 22911). Lancet 380, 2018–2027 (2012).
Parker, C. et al. Radiotherapy and androgen deprivation in combination after local surgery (RADICALS): a new Medical Research Council/National Cancer Institute of Canada phase III trial of adjuvant treatment after radical prostatectomy. BJU Int. 99, 1376–1379 (2007).
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Detti, B., Scartoni, D. Benefit and safety of adjuvant radiation therapy. Nat Rev Urol 10, 131–133 (2013). https://doi.org/10.1038/nrurol.2012.260
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DOI: https://doi.org/10.1038/nrurol.2012.260
