Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Ronald Petersen developed the concept of mild cognitive impairment (MCI) in the late 1990s. The concept has since been expanded to include several subtypes, with amnestic MCI being recognized as a risk state for Alzheimer's disease. This Viewpoint highlights the benefits of retaining the MCI classification, both from a research and from a clinical point of view.
Mild cognitive impairment has become a popular concept for classifying the boundaries between normal aging and dementia, but is it a legitimate diagnosis? In this Viewpoint article, Peter Whitehouse argues that the concept of mild cognitive impairment is fundamentally flawed and driven to a large extent by stakeholder interests.
Most human herpesviruses are neurotropic and have the capability to cause serious acute and chronic neurological diseases of the nervous system. In this article, Gilden et al. review current knowledge regarding the clinical features, pathogenesis and treatment of the various neurological complications that can result from herpesvirus infections.
Fabry's disease is an X-linked lysosomal storage disorder, the primary pathology of which is accumulation of glycosphingolipids in cells throughout the body, including the nervous system. Neurological symptoms, which include pain, abnormal sensations and stroke, are evident early in the disease course. In this Review, Møller and Jensen highlight the importance of recognizing these symptoms in order to ensure a rapid diagnosis.
