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Nature Reviews Nephrology 5, 612–614 (1 November 2009) | doi:10.1038/nrneph.2009.165
Glomerular disease: Sugars and immune complex formation in IgA nephropathy
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Abstract
Mesangial deposition of IgA is the principal trigger for the development of glomerulonephritis in IgA nephropathy (IgAN). Recurrence of IgA deposition in the majority of recipients of renal allografts suggests that this IgA is derived from a circulating pool of pathogenic IgA molecules.
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