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Successful pregnancy in a patient with Landesman's Group C autosomal dominant polycystic kidney disease

Nature Clinical Practice Nephrology volume 4, pages 227–231 (2008)Cite this article

Abstract

Background A female with autosomal dominant polycystic kidney disease was followed up over the course of four pregnancies. Her first three pregnancies were unsuccessful. Her fourth pregnancy resulted in a live birth, but at what expense?

Investigations The diagnosis of autosomal dominant polycystic kidney disease was confirmed by ultrasound imaging. Physical examination, blood pressure measurement, and urine and blood analyses were performed at each follow-up visit.

Diagnosis Deterioration of renal function following multiple complicated pregnancies.

Management Attention to blood pressure and proteinuria delayed initiation of dialysis, but effects of the number of pregnancies took their toll. The patient was started on hemodialysis and underwent renal transplantation.

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Figure 1: Progression of autosomal dominant polycystic kidney disease (as measured by serum creatinine levels) and proteinuria in relation to the patient's age and four pregnancies.

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Authors and Affiliations

  1. M Mohteshamzadeh is a Consultant Physician and Nephrologist at the Royal Berkshire NHS Foundation Trust, Reading, A Coutinho is a Senior House Officer and CF Wong is a Consultant Physician and Nephrologist at the Aintree University Hospital Foundation Trust, Liverpool,

    Mobin Mohteshamzadeh, Andrew Coutinho & Christopher F Wong

  2. I Erekosima is a Staff Grade Nephrologist and R Rustom is a Senior Lecturer and an honorary Consultant Nephrologist at the Royal Liverpool University Hospital, Liverpool, UK.,

    Ibi Erekosima & Rana Rustom

Authors
  1. Mobin Mohteshamzadeh
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  2. Andrew Coutinho
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  3. Ibi Erekosima
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  4. Rana Rustom
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  5. Christopher F Wong
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Corresponding author

Correspondence to Christopher F Wong.

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The authors declare no competing financial interests.

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Mohteshamzadeh, M., Coutinho, A., Erekosima, I. et al. Successful pregnancy in a patient with Landesman's Group C autosomal dominant polycystic kidney disease. Nat Rev Nephrol 4, 227–231 (2008). https://doi.org/10.1038/ncpneph0748

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  • DOI: https://doi.org/10.1038/ncpneph0748

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