Abstract
Background A 42-year-old man presenting with flank pain was found to have renal failure with severe hypocomplementemia and eosinophilia.
Investigations Physical examination, laboratory testing, renal ultrasonography, and renal biopsies.
Diagnosis Acute immune-complex-mediated tubulointerstitial nephritis.
Management Immunosuppressive therapy with 1 mg/kg/day prednisone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cavallo T (1998) Tubulointerstitial Nephritis. In Heptinstall's Pathology of the Kidney, edn 5, 667–724 (Eds Jennette JC et al.) Philadelphia: Lippincott Raven Publishers
Appel GB and Kunis CL (1983) Acute tubulo-interstitial nephritis: contemporary issues. In Nephrology, 151–185 (Eds Cotran RS et al.) New York: Churchill Livingstone
Hyun J and Galen MA (1981) Acute interstitial nephritis—a case characterized by increase in serum IgG, IgM, and IgE concentrations, eosinophilia, and IgE deposition in renal tubules. Arch Intern Med 141: 679–681
Tokumoto M et al. (1999) Acute interstitial nephritis with immune complex deposition and MHC class II antigen presentation along the tubular basement membrane. Nephrol Dial Transplant 14: 2210–2215
Kambham N et al. (2001) Idiopathic hypocomplementemic interstitial nephritis with extensive tubulointerstitial deposits. Am J Kidney Dis 37: 388–399
Wilson CB (1989) Study of the immunopathogenesis of tubulointerstitial nephritis using model systems. Kidney Int 35: 938–953
Brentjens JR et al. (1974) Extra-glomerular lesions associated with deposition of circulating antigen-antibody complexes in kidneys of rabbits with chronic serum sickness. Clin Immunol Immunopathol 3: 112–126
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Vaseemuddin, M., Schwartz, M., Dunea, G. et al. Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis. Nat Rev Nephrol 3, 50–58 (2007). https://doi.org/10.1038/ncpneph0347
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ncpneph0347