News & Comment

Repetitive sensory input induces long-term potentiation of pyramidal cell synapses in mouse somatosensory cortex by activation of higher-order thalamic projections and disinhibition of local interneurons.

In mice, long-term potentiation of hippocampal–nucleus accumbens synapses is required for the formation of reward-related memories.

A study shows that application of spatiotemporally patterned epidural electrical stimulation alongside rehabilitation allowed individuals with spinal cord injury and severe locomotor deficits to walk with limited assistance.

Meal-associated thermogenesis in brown fat is triggered by the gut hormone secretin and signals to the brain to promote satiation in mice.

Two studies show that tau pathology drives the expression of complement molecules that in turn promote the phagocytosis of synapses and neuroinflammation.

Dopamine released in the rodent prefrontal cortex increases the signal-to-noise ratio of responses to aversive stimuli that are transmitted to the periaqueductal grey.

A study shows that during brain development in mice, CD47 prevents excessive synaptic pruning by microglia.

A population of spinal excitatory interneurons can be targeted for the maintenance of respiratory function after spinal cord injury in mice.

Dendritic mitochondria in stimulated neurons undergo fission that is required for long-term potentiation.

A new study finds that, in mice, location-related signals affect activity in the primary visual cortex.

Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe

In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits.

Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum.

Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.

Hippocampal cannabinoid 1 receptors are shown to be involved in the formation of incidental associations between pairs of low-salience sensory stimuli, which can then become indirectly associated with certain cues and thus influence behaviour.

Mice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.

Two studies show that the claustrum delivers inhibition to different parts of the cortex — the prefrontal cortex and auditory cortex.

Spontaneous activity in the developing auditory system is maintained by a homeostatic mechanism and is important for cochlear neuron subtype specification.

Progressive hyperpolarization of ventricular zone progenitors regulates their sequential differentiation and migration in mouse primary sensory cortex.

A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival.