News & Comment

Different defensive responses are characterized by transient behavioural and cardiac components, which are constrained by cardiovascular dynamics occurring across the duration of threat exposure.

Seung-Hee Lee describes findings published in 2000 that gave us insight into the principles by which different types of GABAergic synapses are organized in cortical networks.

In a mouse model of tauopathy, neurodegeneration is dependent on the gut microbiota and is affected by apolipoprotein E isoform expression.

Akiko Hayashi-Takagi discusses the discovery of dendritic ‘NMDA spikes’ in 2000 and its transformation of our understanding of neural processing.

In both human radiation-induced brain injury and a mouse model of this condition, activated microglia release chemokines that attract cytotoxic T cells from the periphery to the lesion site, and this exacerbates neuronal damage in the area.

The representational geometry of neural population activity in the somatosensory cortex of mice allows for high flexibility needed to perform complex tasks and for generalization to novel tasks at the same time.

A study in mice reveals the neural pathway through which light regulates glucose metabolism.

In this Journal Club, Janelle Drouin-Ouellet describes the 1989 paper that provided the first evidence for mitochondrial dysfunction in individuals with idiopathic Parkinson disease.

Ketamine-induced dissociated states in mice result from the suppression and activation of cortical pyramidal neuron populations that are active and silent during wakefulness, respectively.

A growing body of epidemiological evidence linking air pollution to multiple brain disorders suggests that these adverse effects are produced by mechanisms that are shared across these disorders. More stringent, targeted regulatory policies may therefore be required to ensure public health protection.

Hyperactivity in a subset of lateral septum neurons inhibits social reward processing and drives social avoidance following chronic social defeat in mice.

Deletion of Gabrb3, which encodes the β3 subunit of the GABA_A receptor selectively in pyramidal neurons of developing mouse sensory cortex, increased contralateral connectivity, network synchrony and sensitivity to tactile stimuli, suggesting that this receptor is involved in refinement of interhemispheric sensory pathways.

Evidence for the presence of silent synapses in the visual cortex of adult mice is uncovered.

In this Journal Club, Xiang Yu describes a 1986 study that provided crucial evidence for synaptic pruning in cortical development.

Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder.

The increased tissue stiffness that results from the presence of Aβ aggregates activates microglial mechanosensitive PIEZO1 channels and drives Aβ engulfment, reducing plaque burden, synapse loss and spatial memory impairment in mice.

A gut–brain circuit that mediates retching and nausea in response to enterotoxins and chemotheraputic drugs is characterized in mice.

Mackenzie Mathis highlights an essay by Vernon Mountcastle that shaped our understanding of the organization and function of the neocortex.

In mice, a neurodegenerative pathway involving Tbk1 gene mutations and chromosome 9 open reading frame 72 repeat expansions impairs endosome maturation and induces cytoplasmic TBP-43 aggregation.

Barosensitive neurons in the medullary nucleus of the solitary tract can decrease wakefulness and increase non-REM sleep in mice through the same circuitry that regulates cardiovascular function.