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Increasing levels of glial-derived neurotrophic factor using a gene-therapy approach in a macaque model of alcohol use disorder resulted in a lower tendency to relapse into alcohol consumption after a period of abstinence.
The stress associated with early-life social deprivation in mice results in corticosterone-driven overstimulation of cortical synapse removal by astrocytes and behavioural abnormalities in mature animals.
Cardiac disease drives the denervation of the pineal gland, resulting in a loss of neural control of melatonin release and disrupted sleep–wake patterns.
During cortical development, direct neurogenesis was found to generate key glutamatergic projection neuron subclasses and indirect neurogenesis generated and amplified specific subpopulations within these subclasses.
A co-released inhibitory neurotransmitter and stimulatory neuropeptide are shown to act on different timescales to enhance circuit output and optimize behaviour.
The increase in blood corticosterone triggered by the release of proinflammatory cytokines is shown to involve vagal regulation of a parabrachial nucleus–paraventricular nucleus pathway.
The binding of psychedelics to the BDNF receptor TrkB boosts plasticity in cultured neurons and underlies the antidepressant-like effects of these compounds in mice.
The number of neural stem cells in the brain decreases with age, which in the dentate gyrus of older mice is associated with a lower SIRT7-mediated mitochondrial unfolded protein response and reduced neural stem cell maintenance and neurogenesis.