News & Comment

In mice, a neurodegenerative pathway involving Tbk1 gene mutations and chromosome 9 open reading frame 72 repeat expansions impairs endosome maturation and induces cytoplasmic TBP-43 aggregation.

Barosensitive neurons in the medullary nucleus of the solitary tract can decrease wakefulness and increase non-REM sleep in mice through the same circuitry that regulates cardiovascular function.

Preventing transient defects in postnatal cortical circuit function limits disease progression in a mouse model of Huntington disease.

Fluorescent sensors of molecular activity have revolutionized our knowledge of the brain. However, their signals report a reaction between the target and the sensor molecules rather than the activity of interest per se. Thus, understanding the location, sensitivity and imaging environment of a sensor should help to avoid misinterpretation of its readout.

The modern human variant of the gene transketolase-like 1, but not the Neanderthal variant, promotes the production of basal radial glia during neocortical development.

Axo-ciliary synapses that enable rapid signalling to the nucleus are identified in the mouse hippocampus.

Neuromodulation with specific frequencies at specific brain locations selectively enhances either working memory or long-term memory in older adult humans.

A study in male mice finds that neurons in the bed nucleus of the stria terminalis shape hypothalamic neural representations to control the transition from appetitive to consummatory innate social behaviour towards conspecifics of both sexes.

A new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.

Combining high-throughput fluorescence-activated cell sorting and single-cell RNA sequencing, neurons with and without neurofibrillary tangles from people with Alzheimer disease were shown to have different molecular signatures.

Subtypes of pyramidal neurons influence the transcriptomic states of nearby microglia in the mouse somatosensory cortex.