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Microglia activation, BDNF release and the subsequent effect on Cl−homeostasis in spinal lamina I neurons have been shown to play key parts in the hyperalgesia side effect of chronic morphine.
Protein kinase Mζ (PKMζ) is thought to be essential for the maintenance of long-term potentiation (LTP) and memory, but two new studies show that mice lacking PKMζ have normal memories and can undergo normal LTP, casting doubt on the importance of PKMζ for these processes.
The recruitment of V2a interneurons to increase swimming speed in zebrafish is incremental and is determined by the combined effect of their excitatory synaptic currents and input resistance.
