News & Comment

Neurogenesis — in infancy or adulthood — induces forgetting of established memories.

Dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area co-release GABA in the striatum that is not synthesizedde novobut rather is taken up by presynaptic GABA transporters.

Three studies show that exposure to young blood improves brain and muscle function in aged mice.

Synchronized, high-frequency gamma oscillations contribute to successful decision making in a working-memory task in mice and may, therefore, reflect content in working memory entering the animal's 'awareness'.

A new study shows that reducing mutant huntingtin expression in both striatal and cortical neurons is required to prevent disease pathogenesis in a mouse model of Huntington's disease.

Astrocytes in dorsal and ventral regions of the spinal cord differentially express semaphorin 3A, which mediates the proper development of sensorimotor circuits.

Two studies provide evidence for a critical period in the development of the olfactory system in mice.

Axons of cortical pyramidal neurons have diverse profiles of myelin coverage.

An endogenous inhibitor of mTORC1 is essential for stress-induced synapse loss and depression-like behaviour in rodents.

Two studies show that epidermal Merkel cells actively influence touch-evoked activity in sensory neurons and that the transduction of sustained light touch is dependent on PIEZO2 expressed by Merkel cells.

Both GABAergic and glutamatergic projections can modulate the strength of electrical coupling between inferior olive neurons and alter neuron synchronization in the cerebellar inferior olive.

Neuronally expressed major histocompatibility complex class I molecule H2-D^bregulates structural and functional plasticity at retinogeniculate synapses.

Activation of microglial complement receptor 3 by an inflammatory stimulus in the presence of hypoxia induces long-term depression of synaptic transmission in the hippocampus.

The transcription factor REST has a neuroprotective role in the healthy ageing brain that is disrupted in Alzheimer's disease.

An event that is experienced from an 'out-of-body' perspective is remembered less well and its recall does not induce the usual pattern of hippocampal activation.

Opioids, acting mainly via δ-opioid receptors, may provide broad control of cutaneous mechanosensation, including touch.

Olfactory receptors signal through G protein βγ subunits to silence the expression of other olfactory receptors within a single olfactory sensory neuron.

Connexin 30 regulates synaptic transmission by controlling the extension of astrocytic processes into the synaptic cleft.

Adipose-derived interleukin-1β may mediate memory deficits in a mouse model of obesity.

The period length of the circadian clock in the suprachiasmatic nucleus can be modulated by changes in DNA methylation induced by shortening the light–dark cycle.