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  • In mouse primary visual cortex, subpopulations of layer six principal cells form distinct microcircuits that are involved in visual processing.

    • Darran Yates
    Research Highlight
  • The existing properties of neurons in a network restrict its ability to learn to generate new activity patterns.

    • Katherine Whalley
    Research Highlight
  • The emotional valence of a memory can be changed, and this probably involves a change in the connectivity between hippocampal and amygdalar memory traces.

    • Leonie Welberg
    Research Highlight
  • Neurons derived from human induced pluripotent stem cells harbouring a mutation in disrupted in schizophrenia 1 exhibit synaptic deficits.

    • Darran Yates
    Research Highlight
  • In mice, miR-34a-mediated downregulation of Notch signalling in the basolateral amygdala enables fear memory consolidation.

    • Darran Yates
    Research Highlight
  • Astrocytes contribute to the maintenance of fast synchronous activity in the hippocampus and have a role in recognition memory.

    • Katherine Whalley
    Research Highlight
  • High levels of central transforming growth factor-β1 induce hypothalamic inflammation and lead to hyperglycaemia and glucose intolerance.

    • Leonie Welberg
    Research Highlight
  • A subpopulation of neurons in a subdivision of the central amygdala have been found to mediate diverse anorexigenic signals.

    • Natasha Bray
    Research Highlight
  • Endostatin acts as a trans-synaptic signal to promote presynaptic homeostasis at the fly neuromuscular junction.

    • Darran Yates
    Research Highlight
  • Mutant huntingtin pathology is shown to propagate between neurons and contribute to neurodegeneration.

    • Katherine Whalley
    Research Highlight
  • Austism-linked mutations in neuroligin 3 promote repetitive behaviour in mice by targeting a striatal circuit.

    • Darran Yates
    Research Highlight
  • In mice with mechanical hyperalgesia, reactivation of the sensitized pain pathways renders the hyperalgesic state labile and susceptible to being reversed.

    • Darran Yates
    Research Highlight
  • A study by Krepleet al. shows that acid-sensitive ion channel 1A in the nucleus accumbens inhibits cocaine-related synaptic plasticity and cocaine-conditioned behaviour in rodents.

    • Natasha Bray
    Research Highlight
  • Noradrenaline released during arousal controls the ability of astrocytes to respond to local neuronal activity.

    • Leonie Welberg
    Research Highlight
  • The anti-ageing factor Klotho modulates cognition independently of its effects on ageing.

    • Leonie Welberg
    Research Highlight
  • Pain-sensitive sensory neurons in the dorsal root ganglion release calcitonin gene-related peptide, which could over time have long-term consequences on metabolism and longevity by reducing pancreatic release of insulin.

    • Natasha Bray
    Research Highlight
  • CB1 cannabinoid receptors at the terminals of glutamatergic corticostriatal neurons exert neuroprotective effects by preventing excitotoxicity.

    • Leonie Welberg
    Research Highlight
  • A high-fat diet causes persistent changes in the structure and function of the mouse olfactory system.

    • Katherine Whalley
    Research Highlight
  • Stimulation of sleepers' brains with 40 Hz currents during rapid eye movement sleep can induce lucid dreaming.

    • Natasha Bray
    Research Highlight