Neurodegenerative disease: Understanding and preventing total catastrophe | PDF (201 KB)

p323 | doi:10.1038/nrn2390

Synaptic plasticity: A depressing TRP | PDF (197 KB)

p324 | doi:10.1038/nrn2376

Neuroprotection: Staying active = staying alive | PDF (157 KB)

p325 | doi:10.1038/nrn2387

Neurogenetics: Unusual suspects | PDF (122 KB)

p326 | doi:10.1038/nrn2380

Neuroanatomy: A split (mid)brain for dopamine | PDF (222 KB)

p326 | doi:10.1038/nrn2381

Microglia: Giving out dangerous signals | PDF (219 KB)

p326 | doi:10.1038/nrn2383

Glia: Space invaders | PDF (179 KB)

p328 | doi:10.1038/nrn2375

Molecular neuroscience: Stress hormones Trk neurons into survival | PDF (170 KB)

p328 | doi:10.1038/nrn2382

Cell fate: The path to neurogenesis | PDF (402 KB)

p329 | doi:10.1038/nrn2378

GABA_A receptor trafficking and its role in the dynamic modulation of neuronal inhibition

Tija C. Jacob, Stephen J. Moss & Rachel Jurd

p331 | doi:10.1038/nrn2370

GABA_A receptors mediate most inhibitory synaptic transmission, and their assembly and trafficking in neurons is tightly regulated. Moss and colleagues review our current knowledge about the molecular mechanisms that regulate GABA_A receptor trafficking and their contribution to neuronal function.

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Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

Lorenzo A. Cingolani & Yukiko Goda

p344 | doi:10.1038/nrn2373

Actin filaments are the major cytoskeletal elements at the pre- and postsynaptic terminals. Cingolani and Goda discuss how the organization and dynamics of actin filaments are central to the coordination of synapse structure and function.

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Plasticity of intrinsic neuronal properties in CNS disorders

Heinz Beck & Yoel Yaari

p357 | doi:10.1038/nrn2371

The intrinsic properties of a neuron profoundly influence neuronal function and are governed by the ion channels found in different neuronal compartments. Here, Beck and Yaari discuss the mechanisms underlying the plasticity of these properties in various CNS disorders.

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General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

Nicholas P. Franks

p370 | doi:10.1038/nrn2372

The molecular targets of anaesthetics and the neuronal mechanisms through which they induce reversible loss of consciousness have been long-standing mysteries. This Review discusses the most important anaesthetic targets and the implications of the latest imaging studies, which show that there are striking similarities between anaesthetic-induced loss of consciousness and deep sleep.

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• Supplementary information

Metaplasticity: tuning synapses and networks for plasticity

Wickliffe C. Abraham

p387 | doi:10.1038/nrn2356

Synaptic plasticity is central to learning mechanisms, but what keeps the plasticity in check? Abraham reviews our current understanding of the mechanisms of metaplasticity — the plasticity of synaptic plasticity — and considers its importance for nervous system function and disease.

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