Table of contents
From the editors
p809 | doi:10.1038/nrn2267
Research Highlights
Ion channels: Spicing up local anaesthetics | PDF (1,048 KB)
p811 | doi:10.1038/nrn2265
Affective disorders: Less SAD with more sun and serotonin | PDF (225 KB)
p812 | doi:10.1038/nrn2263
In brief
Learning and memory | Synaptogenesis | Neurodegenerative diseases | Neuroprotection | PDF (94 KB)
p812 | doi:10.1038/nrn2272
Circadian rhythms: A father's influence | PDF (290 KB)
p813 | doi:10.1038/nrn2262
Technology: TMS reveals its workings | PDF (304 KB)
p813 | doi:10.1038/nrn2268
Systems Neuroscience: No food in the CART | PDF (213 KB)
p814 | doi:10.1038/nrn2266
Molecular neurobiology: Chained together | PDF (226 KB)
p814 | doi:10.1038/nrn2270
In the news
Fair play | PDF (78 KB)
p814 | doi:10.1038/nrn2273
In brief
Neuroimaging | Neuronal migration | Cognitive neuroscience | Glia | PDF (93 KB)
p815 | doi:10.1038/nrn2271
Learning and memory: Remodel to reconsolidate | PDF (249 KB)
p816 | doi:10.1038/nrn2261
Neurodegenerative diseases: The LINGO of remyelination | PDF (311 KB)
p816 | doi:10.1038/nrn2269
Computational neuroscience: Modules of memory | PDF (164 KB)
p817 | doi:10.1038/nrn2264
Reviews
Neuronal regulation of alternative pre-mRNA splicing
Qin Li, Ji-Ann Lee & Douglas L. Black
p819 | doi:10.1038/nrn2237
Alternative splicing generates much of the protein diversity that is required for many aspects of nervous system development and function. Black and colleagues describe the roles of alternative splicing in the nervous system and the mechanisms by which splicing is regulated.
Genomic imprinting effects on brain development and function
Lawrence S. Wilkinson, William Davies & Anthony R. Isles
p832 | doi:10.1038/nrn2235
For some genes, the two alleles are differentially expressed depending on whether they are inherited from the mother or the father. Wilkinson and colleagues review how this intriguing phenomenon plays a part in brain development and function.
Synaptic plasticity and addiction
Julie A. Kauer & Robert C. Malenka
p844 | doi:10.1038/nrn2234
Drugs of abuse alter synaptic plasticity mechanisms in key brain circuits. Kauer and Malenka review the drug-induced synaptic modifications that take place in the mesolimbic dopamine system, which is central to reward processing and contributes to addiction.
Patterning and axon guidance of cranial motor neurons
Sarah Guthrie
p859 | doi:10.1038/nrn2254
During vertebrate development a transcription factor 'code' specifies the identity of motor neurons. In this article, Sarah Guthrie reviews the latest findings on the differentiation programmes of cranial motor neurons and highlights the importance of diffusible axon guidance molecules for the correct navigation of these neurons to the muscles that control the head and neck.
Article series: Memory systems
Recognition memory and the medial temporal lobe: a new perspective
Larry R. Squire, John T. Wixted & Robert E. Clark
p872 | doi:10.1038/nrn2154
Debate continues regarding the neural substrates of recollection and familiarity, the two components of recognition memory. Squire and colleagues review the data and provide a new perspective, arguing against a neuroanatomical separation of these processes in the medial temporal lobe.
Perspectives
Science and society
Cannabis, the mind and society: the hash realities
Robin M. Murray, Paul D. Morrison, Cécile Henquet & Marta Di Forti
p885 | doi:10.1038/nrn2253
For millennia, cannabis has been used for its relaxing and medicinal properties. Murray and colleagues shed light on recent findings concerning the potential adverse effects of cannabis use and discuss some societal issues that might benefit from research into the effects of cannabis on the brain.
Opinion
Chemokines: a new class of neuromodulator?
William Rostène, Patrick Kitabgi & Stéphane Mélik Parsadaniantz
p895 | doi:10.1038/nrn2255
Chemokines were discovered as cytokines that have chemotactic properties. They are receiving renewed attention, this time from neuroscientists, owing to the possibility that they might act as neurotransmitters or neuromodulators. In a provocative Opinion article, Rostène and colleages review the evidence for this possibility.
Erratum: Space and time in visual context
Odelia Schwartz, Anne Hsu & Peter Dayan
| doi:10.1038/nrn2259
Corrigendum: Pathologically activated therapeutics for neuroprotection
Stuart A. Lipton
| doi:10.1038/nrn2260
