TABLE 1 | Developmental shifts in axon guidance factor distribution

From the following article:

Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?

Noam Y. Harel and Stephen M. Strittmatter

Nature Reviews Neuroscience 7, 603-616 (August 2006)

doi:10.1038/nrn1957

Guidance factorsDevelopment Adult Injury Refs
 Spinal cordForebrainSpinal cordForebrainSpinal cordForebrain 

up arrow, increase; down arrow, decrease; BG, basal ganglia; BS, brain stem; CBL, cerebellum; CC, central canal; CSMN, corticospinal motor neurons; Cx, cortex; CST, corticospinal tract; D, dorsal; DCC, deleted in colorectal cancer; DH, dorsal horn; DRG, dorsal root ganglia; fibros, fibroblasts; FP, floor plate; HC, hippocampus; IN, interneurons; macros, macrophages; MN, motor neurons; nd, not determined; + (ns), present but localization not further specified; OB, olfactory bulb; OGD, oligodendrocytes; ON, optic nerve; RGC, retinal ganglion cells; RP, roof plate; SN, substantia nigra; SVZ, subventricular zone; V, ventral; VH, ventral horn.

Netrin 1FP, ventral CCStriatum, HC, OB, optic cupD = V; neurons and OGDStriatum, SN, CBL, retinaDorsal hemisection: up arrow in invading fibros/macrosCBL lesion: up arrow in invading fibros/macros120,208–211
DCCVH, commisural axons, dorsal CCCx, striatum, CBL, retinaV>D; grey = white (weak expression)HC, CBL, retina (weak expression)ndON injury: 44% down arrow; CBL injury: no change119,120,208,211–214
UNC5H2RP, DRGOptic cupD = V grey (stronger expression than in embryo)CBLndON injury: 26% down arrow45,119,120,215
Ephrin A2+ (ns)HC, OB, BS+ (ns)HC, OB, BS, retinandON injury: up arrow in caudal superior colliculus216–218
EphA4V>DSVZ, BG, HC, CBL, retinaDH>VHCx, striatum, SN, HC, CBL, BSTransection: up arrow in proximal CST stumps and astrocytesHC injury: no change219–225
Ephrin B3MidlineHCOGDCx, HC, CBLTransection: mild down arrowON injury: up arrow in RGC39,54,219,225,226
EphB2VHCx, HC, CBL, BSFibrosHCTransection: up arrow in fibrosHC injury: no change219,223,227,228
SLIT1FP>MNDiffuseD>VDiffuseDorsal hemisection: up arrow in macros/fibrosCBL injury: up arrow in macros26,211,229,230
SLIT3FP, MN (weak expression)HC, OB, BSV>DDiffuseDorsal hemisection: large up arrow in macros/fibrosCBL injury: no change26,211,230
ROBO1Commisural axons, MNDiffusendDiffusendCBL injury: no change26,211,230,231
ROBO3Commissural axons, ventral IN (not MN)BSndCBLndCBL injury: no change30,211,232
Sema3AVH, ventral CCCx, HCVHHC, OB, CBLStab injury: up arrow in fibrosCortical or olfactory stab injury: up arrow in fibros233–238
Sema3FndCx, BGIntermediate IN (weak expression)ndStab injury: weak up arrow in fibrosnd235,236,238,239
NP1DRG>dorsal funiculus>MNCx, HC, OBDRGCSMNDorsal hemisection: persist/no change in DRGnd233–235,238,240
PlexA1Diffuse, sympathetic gangliandDRGDiffuse CxDorsal hemisection: persist/no change in DRGnd235,238,241
PlexB1CCSVZndSVZ, CBLndnd242
RGM-AFP>VHSVZ; optic mesenchymeNeurons and OGDndDorsal hemisection: up arrow in macros and OGDnd40,243,244
NeogeninVentral midlineDiffuseVH>DH (weak expression)+ (ns)ndnd119,212–214,245

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