Review

Nature Reviews Neuroscience 7, 449-463 (June 2006) | doi:10.1038/nrn1905

In vivo imaging of the diseased nervous system

Thomas Misgeld1 & Martin Kerschensteiner1,2  About the authors

Top

In vivo microscopy is an exciting tool for neurological research because it can reveal how single cells respond to damage of the nervous system. This helps us to understand how diseases unfold and how therapies work. Here, we review the optical imaging techniques used to visualize the different parts of the nervous system, and how they have provided fresh insights into the aetiology and therapeutics of neurological diseases. We focus our discussion on five areas of neuropathology (trauma, degeneration, ischaemia, inflammation and seizures) in which in vivo microscopy has had the greatest impact. We discuss the challenging issues in the field, and argue that the convergence of new optical and non-optical methods will be necessary to overcome these challenges.

Author affiliations

  1. Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
  2. Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig-Maximilians University, Munich, Germany.

Correspondence to: Thomas Misgeld1 Email: tmisgeld@mcb.harvard.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Spinal cord alive and kicking

Nature Medicine News and Views (01 Apr 2004)

Regenerating nerves follow the road more traveled

Nature Neuroscience News and Views (01 Sep 2002)

See all 3 matches for News And Views