Table of contents
From the editors
p903 | doi:10.1038/nrn2053
Research Highlights
Neurological disorders: Food for thought
p904 | doi:10.1038/nrn2049
Synaptic physiology: Making connections through MeCP2
p905 | doi:10.1038/nrn2041
Cell biology of the neuron: Shootin 1 for the axon
p906 | doi:10.1038/nrn2045
In brief
Synaptogenesis | Development | Neurogenetics | Pain
p906 | doi:10.1038/nrn2050
Sensory systems: The silenced synapse
p906 | doi:10.1038/nrn2052
Behavioural neuroscience: It's good to give
p907 | doi:10.1038/nrn2047
Circadian rhythms: Feeding time
p908 | doi:10.1038/nrn2046
Neuroendocrinology: Balancing bodily functions
p908 | doi:10.1038/nrn2048
Cancer: Rooting out resistance
p909 | doi:10.1038/nrn2051
Reviews
The neuronal microRNA system
Kenneth S. Kosik
p911 | doi:10.1038/nrn2037
Emerging evidence implicates members of a recently identified class of regulatory molecules, microRNAs, as having important roles in nervous system development and function. Kenneth Kosik reviews these findings and discusses the future challenges facing the field.
High-conductance potassium channels of the SLO family
Lawrence Salkoff, Alice Butler, Gonzalo Ferreira, Celia Santi and Aguan Wei
p921 | doi:10.1038/nrn1992
SLO channels comprise a family of high-conductance potassium channels with several distinctive features that give them the versatility to function in various cellular contexts. The authors describe the key properties and physiological roles of these channels in the nervous system.
Axonal conduction and injury in multiple sclerosis: the role of sodium channels
Stephen G. Waxman
p932 | doi:10.1038/nrn2023
Understanding the pathophysiological mechanisms that underlies neurological dysfunction in multiple sclerosis is essential for effective therapeutic intervention. Waxman reviews the evidence that aberrant Na+ channel expression contributes to restoration of axonal conduction, axonal injury and cerebellar dysfunction in multiple sclerosis.
The mirror neuron system and the consequences of its dysfunction
Marco Iacoboni and Mirella Dapretto
p942 | doi:10.1038/nrn2024
Mirror neurons are specialized cells that fire both when an animal performs an action and when it observes others performing that action. A role for these cells in social cognition is emerging, and their dysfunction is now implicated in autism.
Article series: Neuroimaging
Towards multimodal atlases of the human brain
Arthur W. Toga, Paul M. Thompson, Susumu Mori, Katrin Amunts and Karl Zilles
p952 | doi:10.1038/nrn2012
Brain atlases have existed for centuries; however, these traditional atlases have many limitations, which promise to be overcome with new brain imaging techniques. Toga and colleagues highlight exciting advances in brain mapping technology and the ongoing progress towards integrative multimodal atlases.
Perspective
Opinion
The short-latency dopamine signal: a role in discovering novel actions?
Peter Redgrave and Kevin Gurney
p967 | doi:10.1038/nrn2022
The phasic dopamine response is traditionally thought to signal reward prediction errors. Redgrave and Gurney evaluate evidence from studies of basal ganglia circuitry and signal timing, and propose instead that the short-latency dopamine signal is important for discovering novel actions.
Correspondence
Correspondence: Genes are not our destiny: the somatic epitype bridges between the genotype and the phenotype
Debomoy K. Lahiri and Bryan Maloney
| doi:10.1038/nrn2022-c1
